Jerrold M. Olefsky

TL;DR: Sulfonylureas exert potent extrapancreatic effects that partially correct all of the abnormalities present in the type II diabetic state, and after 3 mo of glyburide treatment, glycemic control is markedly improved and this is accompanied by an increase in insulin secretion, no change in cellular insulin receptors, decreased hepatic glucose production rates, and an increased in overall insulin-mediated glucose disposal.

TL;DR: A recent paper shows that the APPL1 adaptor protein binds to the intracellular domain of adiponectin receptors and mediates some of adip onectin's actions, identifying a novel mechanism linking adiponECTin to insulin sensitization.

TL;DR: The data indicate that Shc is essential for stimulation of Ras dependent mitogenesis and gene expression by the G12 coupled thrombin receptor, which occurs specifically through the Shc SH2 domain.

TL;DR: The findings suggest that a high genetic burden confers an adverse lipid profile and predicts attenuated response in LDL-C levels and small LDL particle number to dietary and physical activity interventions aimed at weight loss.

TL;DR: In vitro studies utilizing cultured human fibroblasts indicate that glyburide increases the number of cell-surface insulin receptors and opposes insulin-mediated down-regulation, which suggests that the improvement in target tissue insulin action is the critical determinant in terms of the clinical response to the drug.