J
Jerrold M. Olefsky
Researcher at University of California, San Diego
Publications - 606
Citations - 83310
Jerrold M. Olefsky is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Insulin & Insulin resistance. The author has an hindex of 143, co-authored 595 publications receiving 77356 citations. Previous affiliations of Jerrold M. Olefsky include University of Colorado Boulder & University of Michigan.
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Journal ArticleDOI
The small guanosine triphosphate-binding protein Rab4 is involved in insulin-induced GLUT4 translocation and actin filament rearrangement in 3T3-L1 cells.
Peter Vollenweider,Stuart S. Martin,Tetsuro Haruta,Aaron J. Morris,James G. Nelson,Mireille Cormont,Y. Le Marchand-Brustel,D W Rose,Jerrold M. Olefsky +8 more
TL;DR: Rab4 is a necessary component of the insulin/GLUT4 translocation signaling pathway; the function of Rab4 in this pathway requires GTP binding; Rab4 also participates in the process of insulin-induced membrane ruffling; and Rab3 proteins do not seem to be involved in these processes.
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Prospects for research in diabetes mellitus.
TL;DR: Identification of the genetic components of type 1 and type 2 diabetes is the most important area of research because elucidation of the diabetes genes will influence all efforts toward a mechanistic understanding of the disease, its complications, and its treatment, cure, and prevention.
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Topiramate is an insulin-sensitizing compound in vivo with direct effects on adipocytes in female ZDF rats.
TL;DR: TPM treatment leads to a decrease in plasma glucose and increased in vivo insulin sensitivity; insulin sensitization was observed in adipocytes, but not muscle, when tissues were studied ex vivo or in vitro; and TPM directly enhances insulin action in insulin-resistant adipose cells in vitro.
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Regulation of glucose transport in cultured muscle cells by novel hypoglycemic agents.
Theodore P. Ciaraldi,Kathleen Huber-Knudsen,Kathleen Huber-Knudsen,Matthew G. Hickman,Matthew G. Hickman,Jerrold M. Olefsky,Jerrold M. Olefsky +6 more
TL;DR: The antidiabetic agent troglitazone (CS-045) and a metabolite designated M3 have potent blood glucose-lowering actions and the mechanism of the hypoglycemic effects was investigated in cultured L6 muscle cells.
Journal ArticleDOI
Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects
Kim Ravnskjaer,Meghan F. Hogan,Denise E. Lackey,Laszlo Tora,Sharon Y.R. Dent,Jerrold M. Olefsky,Marc Montminy +6 more
TL;DR: In this paper, the authors showed that histone H3 acetylation at Lys 9 (H3K9Ac) was elevated over gluconeogenic genes and contributed to increased hepatic glucose production during fasting and in diabetes.