J
Jerrold M. Olefsky
Researcher at University of California, San Diego
Publications - 606
Citations - 83310
Jerrold M. Olefsky is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Insulin & Insulin resistance. The author has an hindex of 143, co-authored 595 publications receiving 77356 citations. Previous affiliations of Jerrold M. Olefsky include University of Colorado Boulder & University of Michigan.
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Effects of fasting on insulin binding, glucose transport, and glucose oxidation in isolated rat adipocytes: relationships between insulin receptors and insulin action.
TL;DR: Insulin binding is increased during fasting due to an increased overall binding affinity with no change in receptor number, and glucose oxidation is severely impaired during fasting, indicating impaired intracellular oxidative metabolism.
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Fatty Acid-Induced Insulin Resistance: Decreased Muscle PI3K Activation But Unchanged Akt Phosphorylation
Yolanta T. Kruszynska,Dorothy Sears Worrall,Jachelle M. Ofrecio,Juan P. Frias,Gina Macaraeg,Jerrold M. Olefsky +5 more
TL;DR: NEFA-induced insulin resistance is associated with an impairment of IRS-1 tyrosine phosphorylation and IRS-1-associated PI3K activation, which may lead to impaired glucose transport through an Akt-independent pathway because Akt phosphorylations was unaffected by elevated NEFA levels.
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The insulin receptor. A multifunctional protein.
TL;DR: This organizational model of the insulin receptor predicts the existence of divergent signaling pathways facilitating specific bioeffects, and provides several mechanisms whereby inactive insulin receptors (no kinase activity) can inhibit the function of normal receptors.
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Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity
Wei Ying,Yun Sok Lee,Yi Dong,Jason S. Seidman,Meixiang Yang,Roi Isaac,Jong Bae Seo,Bi-Huei Yang,Joshua Wollam,Matthew Riopel,Joanne C. McNelis,Christopher K. Glass,Jerrold M. Olefsky,Wenxian Fu +13 more
TL;DR: This work identifies two islet-resident macrophage populations, characterized by their anatomical distributions, distinct phenotypes, and functional properties, and defines distinct roles and mechanisms for islet macrophages in the regulation of islet β cells.