J
Jerrold M. Olefsky
Researcher at University of California, San Diego
Publications - 606
Citations - 83310
Jerrold M. Olefsky is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Insulin & Insulin resistance. The author has an hindex of 143, co-authored 595 publications receiving 77356 citations. Previous affiliations of Jerrold M. Olefsky include University of Colorado Boulder & University of Michigan.
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Journal ArticleDOI
PS21 - 100. A PPAR -FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis
Johan W. Jonker,Johan W. Jonker,Jay-Myoung Suh,Annette R. Atkins,Maryam Ahmadian,Pingping Li,Jamie Whyte,Mingxiao He,Henry Juguilon,Yun-Qiang Yin,Colin T. Phillips,Ruth T. Yu,Jerrold M. Olefsky,Robert R. Henry,Michael Downes,Ronald M. Evans +15 more
TL;DR: Although feast and famine cycles illustrate that remodelling of adipose tissue in response to fluctuations in nutrient availability is essential for maintaining metabolic homeostasis, the underlying mechanisms remain poorly understood.
Journal ArticleDOI
Hybrid formation between endogenous mouse and transfected human tyrosine kinase-deficient (A/K1018) insulin receptors leads to decreased insulin sensitivity in 3T3-L1 adipocytes
TL;DR: Hybrid formation is established as an important determinant in the dominant negative nature of the A/K1018 insulin receptor in 3T3-L1 cells.
Journal ArticleDOI
Trans-resveratrol inhibits phosphorylation of Smad2/3 and represses FSHβ gene expression by a SirT1-independent pathway in LβT2 gonadotrope cells.
Debin Lan,Min Lu,Shweta Sharma,Pamela L. Mellon,Jerrold M. Olefsky,Nicholas J. G. Webster,Nicholas J. G. Webster +6 more
TL;DR: The results suggest that resveratrol down-regulates Smad2/3 phosphorylation and suppresses FSHβ expression via a SirT1-independent pathway.
Journal ArticleDOI
The Effect of Interventions to Prevent Type 2 Diabetes on the Development of Diabetic Retinopathy: The DPP/DPPOS Experience
Neil H. White,Qing Pan,Emily B. Schroeder,Emily Y. Chew,Barbara A Blodi,Xavier Pi-Sunyer,Christine Darwin,Mathias Schlögl,David M. Nathan,Barry J. Goldstein,Kevin Furlong,Kellie Smith,J. T. Mendoza,W. W. Wildman,Marsha D. Simmons,Genine Jensen,R. Liberoni,John Spandorfer,C. Pepe,Richard P. Donahue,Ronald N. Goldberg,P. Rowe,A. Giannella,J. Calles,Juliet Sanguily,Paul Cassanova-Romero,Sumaya Castillo-Florez,Hermes Florez,Rajesh Garg,Lascelles Kirby,Olga Lara,Carmen A. Larreal,V. McLymont,J. Mendez,Arlette C. Perry,Patrice G. Saab,B. Veciana,Steven M. Haffner,Helen P. Hazuda,Maria G. Montez,J.J. Isaac,K. Hattaway,Carlos Lorenzo,Arlene Martinez,Monica R. Salazar,Tatiana Walker,Richard F. Hamman,Dana Dabelea,Patricia Nash,Sheila Steinke,L. Testaverde,Jennifer T. Truong,Denise Anderson,Larry B. Ballonoff,Alexis Bouffard,Rebecca S. Boxer,Brian C. Bucca,B. Ned Calonge,Lynne Delve,Martha Farago,James O. Hill,S. R. Hoyer,T. Jenkins,Bonnie T. Jortberg,Dione Lenz,Marsha Miller,T.G. Nilan,Leigh Perreault,David W. Price,Judith G. Regensteiner,Helen M. Seagle,Carissa M. Smith,Brent VanDorsten,Edward S. Horton,Medha Munshi,K. E. Lawton,Catherine Serra Poirier,Kati Swift,S. D. Jackson,Ronald A. Arky,M. Bryant,J. P. Burke,E. Caballero,Karen M. Callaphan,Barbara Fargnoli,T. Franklin,Om P. Ganda,A. Guidi,Mathew Guido,A. M. Jacobsen,L. M. Kula,M. Kocal,Lori Lambert,Sarah Ledbury,M. A. Malloy,Roeland J.W. Middelbeek,M. Nicosia,C. F. Oldmixon,Jocelyn Yu Pan,M. Quitingon,Riley Rainville,S. Rubtchinsky,Ellen W. Seely,Jessica Sansoucy,D. Schweizer,Donald C. Simonson,Fannie Smith,Caren G. Solomon,Jeanne Spellman,James H. Warram,Steven E. Kahn,Brenda Montgomery,B. Fattaleh,C. B. Colegrove,Wilfred Y. Fujimoto,Robert H. Knopp,Edward W. Lipkin,Michelle Marr,Ivy Morgan-Taggart,Anne Murillo,Kayla O’Neal,Dace L. Trence,Lonnese Taylor,April Thomas,Elaine Tsai,Abbas E. Kitabchi,Samuel Dagogo-Jack,Mary E. Murphy,Laura Taylor,Jennifer Dolgoff,Ethel Faye Hampton,William B. Applegate,Michael Bryer-Ash,Debra L. Clark,Sandra L. Frieson,Uzoma N. Ibebuogu,Raed Imseis,Helen Lambeth,Lynne Lichtermann,Hooman Oktaei,H. Ricks,L. M. Rutledge,Amy R. Sherman,Clara Mabel Smith,Judith E. Soberman,Beverly Williamsleaves,Avnisha Patel,Ebenezer Nyenwe,Boyd E. Metzger,Mark E. Molitch,Amisha Wallia,Mariana K. Johnson,Sarah VanderMolen,Daphne T. Adelman,Catherine Behrends,Michelle Westerman Cook,Marian L. Fitzgibbon,Mimi M. Giles,M. Hartmuller,C. Johnson,Diane Larsen,Anne Susan Lowe,Megan Lyman,D McPherson,Samsam C. Penn,Thomas H. Pitts,Renee Reinhart,Susan M Roston,Pamela Schinleber,Charles McKitrick,H. Turgeon,Mary Larkin,Marielle T Mugford,Nopporn Thangthaeng,Fernelle Leander,Kathy Abbott,Ellen J. Anderson,Laurie Bissett,Kristy-Ann Bondi,Enrico Cagliero,Jose C. Florez,Linda M. Delahanty,Valerie Goldman,Elaine Grassa,Lindsey Gurry,Kali Nicole D'Anna,Fernelle Leandre,P. Lou,Alexandra Poulos,Elyse Raymond,Valerie Ripley,Christin E. Stevens,Beverly Tseng,Jerrold M. Olefsky,Elizabeth Barrettonnor,Sunder Mudaliar,Maria Rosario Araneta,Mary Lou Carrion-Petersen,Karen Vejvoda,Sarah S Bassiouni,Madeline Beltran,Lauren N. Claravall,Jonalle M. Dowden,Steven V. Edelman,Pranav S. Garimella,Robert R. Henry,Javiva Horne,Marycie Lamkin,Simona Szerdi Janesch,Diana Leos,William H. Polonsky,Rosaura Ruiz,Jean Smith,Jennifer Torio-Hurley,F. Xavier Pi-Sunyer,Blandine Laferrère,Jane E. Lee,Susan Hagamen,Kim Kelly-Dinham,David B. Allison,Nnenna Agharanya,Nancy J Aronoff,Mara Del Baldo,Jill P. Crandall,Sandra Foo,José A. Luchsinger,Carmen Pal,Kathy Parkes,Mary Beth Pena,Julienne Roman,Eileen Rooney,Gretchen E.H. VanWye,Kristine A. Viscovich,Melvin J. Prince,David G. Marrero,Kieren J. Mather,N. De Groot,Susie Kelly,Marcia A. Jackson,G. E. Mcatee,Paula Putenney,Ronald T. Ackermann,Carolyn M. Cantrell,Yolanda F. Dotson,Edwin S. Fineberg,Megan Fultz,John Guare,Angela M. Hadden,James M. Ignaut,M. Sue Kirkman,Erin O'Kelly Phillips,Kisha L. Pinner,Beverly Porter,Paris Roach,Nancy Rowland,Madelyn L. Wheeler,Robert E. Ratner,Vanita R. Aroda,Michelle F. Magee,Gretchen A. Youssef,Sue Shapiro,Natalie Andon,Catherine Bavido-Arrage,Geraldine Boggs,Marjorie Bronsord,Ernestine Brown,Holly Love Burkott,Wayman Wendell Cheatham,Susan Y Cola,Cindy Evans,Peggy Gibbs,Tracy Kellum,Lilian E. de Leon,Milvia Lagarda,Claresa Levatan,Milajurine T. Lindsay,Asha K. Nair,Jean Park,Maureen D. Passaro,A Silverman,Gabriel I. Uwaifo,Debra Wells-Thayer,Renee Wiggins,Mohammed F. Saad,Karol E. Watson,Maria Budget,Sujata Jinagouda,M.G.Z. Botrous,Anthony Sosa,S. Tadros,Khan Mohd Akbar,Claudia Conzues,Perpetua Magpuri,Kathy Ngo,Amer G. Rassam,Debra Waters,Kathy Xapthalamous,Julio V. Santiago,Angela L. Brown,Ana Cristina Santiago,Samia Das,Prajakta A. Khare-Ranade,Tamara Stich,Edwin B. Fisher,Emma Hurt,Jackie Jones,Tracy Jones,Michelle Kerr,Sherri McCowan,Lucy D. Ryder,Cormarie Wernimont,Christopher D. Saudek,Sherita Hill Golden,Vanessa Bradley,Emily Sullivan,Tracy Whittington,Caroline Abbas,Adrienne Allen,Frederick L. Brancati,S. Cappelli,Jeanne M. Clark,Jeanne Charleston,Janice Freel,Katherine Horak,Alicia Marie Greene,Dawn Jiggetts,Delois Johnson,Hope Joseph,Rita R. Kalyani,Kimberly Loman,Nestoras Mathioudakis,Nisa M. Maruthur,Henry Mosley,John Reusing,Richard R. Rubin,Alafia Samuels,Thomas Shields,Shawn S. Stephens,Kerry J. Stewart,Lee E. Thomas,E Utsey,Paula R Williamson,David S. Schade,Karwyn S. Adams,Carolyn Johannes,C. Dallett Hemphill,Penny Hyde,Janene L. Canady,Leslie F. Atler,Patrick J. Boyle,Mark R. Burge,Lisa Chai,Kathleen Colleran,Ateka Fondino,Ysela Gonzales,Doris A. Hernandez-McGinnis,Patricia Hawkins Katz,Carolyn King,Julia Middendorf,Sofya M Rubinchik,Willette Senter,Harry Shamoon,Janet Brown,Gilda Trandafirescu,Danielle Powell,Elsie Adorno,Liane Cox,H. Duffy,Samuel S. Engel,Allison Friedler,Angela Goldstein,Crystal J. Howardentury,Jennifer Lukin,Stacey Kloiber,Nadege Longchamp,H. Martinez,D. Pompi,Jonathan Scheindlin,Norica Tomuta,Elissa Violino,Elizabeth A. Walker,Judith Wylie-Rosett,Elise Zimmerman,Joel Zonszein,Rena R. Wing,Trevor J. Orchard,Elizabeth M. Venditti,Gaye M. Koenning,M. Kaye Kramer,Marietta Smith,Susan Jeffries,Valarie A. Weinzierl,Susan Barr,Catherine Benchoff,Miriam A. Boraz,Lisa Clifford,Rebecca J. Culyba,Marlene Frazier,Ryan Gilligan,Stephanie Guimond,Susan Harrier,Louann Harris,Andrea M. Kriska,Qurashia Manjoo,Monica Mullen,Alicia Noel,Amy D. Otto,Jessica L Pettigrew,Bonny Rockette-Wagner,Debra Rubinstein,Linda Semler,Cheryl F. Smith,Katherine V. Williams,Tara Wilson,Richard Arakaki,Marjorie K. Mau,Renee W. Latimer,M. Isonaga,Narleen K. Baker-Ladao,Ralph Bow,Nina Bermudez,Lorna Dias,Jillian Inouye,John S. Melish,Kathy Mikami,Pharis Mohideen,Sharon Kaʻiulani Odom,Raynette U. Perry,Robin E. Yamamoto,William C. Knowler,Robert L. Hanson,Vallabh O. Shah,Mary A. Hoskin,Carol Percy,Norman Cooeyate,Camille Natewa,Charlotte Peabody Dodge,Alvera Enote,Harelda Anderson,Kelly J. Acton,Vickie L. Andre,Rosalyn Barber,Shandiin Begay,Peter H. Bennett,Mary Beth Benson,Evelyn C. Bird,Brenda A. Broussard,Marcella Chavez,S.J. Cook,Jeffrey Curtis,Tara Dacawyma,Matthew S. Doughty,Roberta Duncan,Cyndy Edgerton,Jacqueline M. Ghahate,Justin Glass,Marti J. Glass,Dorothy Gohdes,Wendy Lyn Grant,Ellie Horse,Louise E. Ingraham,Merry Jackson,Priscilla Jay,Roylen S. Kaskalla,Karen G. Kavena,David Kessler,Kathy Kobus,Jonathan Krakoff,Jason Kurland,Catherine Manus,C. L. McCabe,Sara Michaels,Tina Morgan,Yolanda Nashboo,Julie Nelson,Steven Poirier,Evette Polczynski,Christopher S. Piromalli,Michael S. Reidy,Jeanine Roumain,Debra Rowse,Robert J. Roy,Sandra Sangster,Janet Sewenemewa,Miranda Smart,Chelsea Lee Spencer,Darryl Parker Tonemah,Rachel Williams,Charlton Wilson,Michelle Yazzie,Ray Bain,Sarah E. Fowler,Michael D. Larsen,Kathleen A. Jablonski,Marinella Temprosa,Tina Brenneman,Sharon L. Edelstein,Solome Abebe,Julie A. Bamdad,Melanie Barkalow,J. Bethepu,Tsedenia Bezabeh,Anna-Claire Bowers,Nicole A. Butler,Jackie Callaghan,Caitlin E. Carter,Costas A. Christophi,Gregory M. Dwyer,Mary A. Foulkes,Yuping Gao,Robert Gooding,Adrienne M. Gottlieb,Kristina L. Grimes,Nisha Grover-Fairchild,Lori Haffner,Heather J. Hoffman,Steve Jones,Tara Jones,Richard J. Katz,Preethy Kolinjivadi,John M. Lachin,Yong Ma,Pamela Mucik,Robert Orlosky,S. M. Reamer,James Rochon,Alla Sapozhnikova,Hanna Sherif,Charlotte Stimpson,Ashley Hogan Tjaden,Fredricka Walker-Murray,Valerie Weinzierl,Santica M. Marcovina,F. Alan Aldrich,J.E. Harting,J. M. Albers,Greg Strylewicz,Anthony A. Killeen,Deanna Gabrielson,Robert Edward Eastman,Judith E. Fradkin,Sanford A. Garfield,Christine G. Lee,Edward W. Gregg,Ming Zhang,D. O'Leary,Gregory M. Evans,Matthew J. Budoff,Chris Dailing,Elizabeth R. Stamm,Ann V. Schwartz,Caroline Navy,Lisa Palermo,Pentti M. Rautaharju,Ronald J. Prineas,Elsayed Z. Soliman,Teresa Alexander,Charles Campbell,Sharon Perkins Hall,Yabing Li,Margaret Mills,Nancy Pemberton,Farida Rautaharju,Zhu Ming Zhang,Julie Hu,S. Hensley,L.C. Keasler,Tonya Marie Taylor,Ronald P. Danis,M. Davis,Larry D. Hubbard,Ryan L. Endres,Deborah Elsas,Samantha Johnson,Dawn Myers,Nancy F. Barrett,Heather Baumhauer,Wendy Benz,Holly Cohn,E Corkery,Kristi Dohm,Amitha Domalpally,V. Gama,A. Goulding,Andrew Ewen,Cynthia Hurtenbach,Daniel Lawrence,Kyle McDaniel,Jeong W. Pak,J.L. Reimers,Ruth W. Shaw,Maria K. Swift,Pamela Vargo,Sheila D. Watson,J. E. Manly,Elizabeth J. Mayer-Davis,Robert Moran,Ted Ganiats,Kristin David,Andrew J. Sarkin,Erik J. Groessl,Naomi M. Katzir,Helen Chong.,William H. Herman,Michael Brändle,Morton B. Brown,David Altshuler,Liana K. Billings,Ling Chen,Maegan Harden,Toni I. Pollin,Alan R. Shuldiner,Paul W. Franks,Marie-France Hivert +613 more
TL;DR: Interventions that delay or prevent the onset of type 2 diabetes in overweight/obese subjects with dysglycemia who are at risk for diabetes do not reduce the development of diabetic retinopathy for up to 20 years.
Journal ArticleDOI
A truncated human insulin receptor missing the COOH-terminal 365 amino acid residues does not undergo insulin-mediated receptor migration or aggregation
TL;DR: Evidence is provided of the roles that regions of the beta-subunit play in the processing of occupied insulin receptors and a decrease in ATP-dependent, coated pit-mediated internalization is provided.