J
Jerrold M. Olefsky
Researcher at University of California, San Diego
Publications - 606
Citations - 83310
Jerrold M. Olefsky is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Insulin & Insulin resistance. The author has an hindex of 143, co-authored 595 publications receiving 77356 citations. Previous affiliations of Jerrold M. Olefsky include University of Colorado Boulder & University of Michigan.
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Substrate specificities of insulin and epidermal growth factor receptor kinases
TL;DR: Results indicate that the insulin and the EGF receptor kinase have different, but overlapping, substrate specificities, which may represent an important mechanism to preserve the specificity of the hormonal signal at the post receptor level.
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NPXY motif in the insulin-like growth factor-I receptor is required for efficient ligand-mediated receptor internalization and biological signaling.
TL;DR: The NPXY motif that was identified in the low density lipoprotein receptor serves as an internalization signal, and subsequent studies have indicated that the NPXY sequence is also an important recognition element for internalization of both insulin and transferrin receptors.
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The metabolic effects of biosynthetic human proinsulin in individuals with type I diabetes.
R. M. Bergenstal,Robert M. Cohen,E. Lever,Kenneth S. Polonsky,J. Jaspan,P. M. Blix,Robert R. Revers,Jerrold M. Olefsky,Orville G. Kolterman,K. Steiner,Alan D. Cherrington,B. Frank,J. H. Galloway,A. H. Rubenstein +13 more
TL;DR: Findings indicate that proinsulin is approximately 7.3% as biologically active as insulin on a molar basis in maintaining glucose control in patients with type I diabetes mellitus and that further studies are necessary to determine whether biosynthetic human proins insulin has a specific role in the treatment of diabetes.
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Effects of Insulin and Insulin-like Agents on the Glucose Transport System of Cultured Human Fibroblasts
TL;DR: C cultured human fibroblasts can serve as an important model for physiologic studies of insulin action and glucose transport, and for studies of pathophysiologic abnormalities of these processes in cells obtained from patients with various disease states.
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Effect of heterozygous PPARγ deficiency and TZD treatment on insulin resistance associated with age and high-fat feeding
TL;DR: It is shown that PPARgamma deficiency partially protects against age-related insulin resistance but does not protect against HF diet-induced insulin resistance.