J
Jerrold M. Olefsky
Researcher at University of California, San Diego
Publications - 606
Citations - 83310
Jerrold M. Olefsky is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Insulin & Insulin resistance. The author has an hindex of 143, co-authored 595 publications receiving 77356 citations. Previous affiliations of Jerrold M. Olefsky include University of Colorado Boulder & University of Michigan.
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Journal ArticleDOI
Insulin treatment reverses the insulin resistance of type II diabetes mellitus.
TL;DR: The postreceptor defect in insulin-stimulated glucose disposal is largely ameliorated by exogenous insulin treatment, suggesting that this defects in insulin action is an acquired abnormality which is secondary to some aspect of the insulin-deficient state.
Journal ArticleDOI
LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes
Pingping Li,Pingping Li,Da Young Oh,Gautam Bandyopadhyay,William S Lagakos,Saswata Talukdar,Olivia Osborn,Andrew M.F. Johnson,Heekyung Chung,Rafael Mayoral,Michael Maris,Jachelle M. Ofrecio,Sayaka Taguchi,Min Lu,Jerrold M. Olefsky +14 more
TL;DR: Observations elucidate a novel role of the LTB4–Ltb4r1 signaling pathway in hepatocyte and myocyte insulin resistance, and show that in vivo inhibition of Ltb4 r1 leads to robust insulin-sensitizing effects.
Increased Adipocyte O 2 Consumption Triggers HIF-1a ,C ausing Inf lammation and Insulin Resistance in Obesity
Yun Sok Lee,Jung-whan Kim,Roman Sasik,Simon Schenk,Heekyung Chung,Anne N. Murphy,Steven M. Watkins,Oswald Quehenberger,Randall S. Johnson,Jerrold M. Olefsky +9 more
TL;DR: In this paper, the authors reported that early in the course of high-fat diet (HFD) feeding and obesity, adipocyte respiration becomes uncoupled, leading to increased oxygen consumption and a state of relative adipocyte hypoxia.
Journal ArticleDOI
Inflammation in obesity, diabetes, and related disorders
TL;DR: In this paper , a review of the current understanding of the mechanisms underlying inflammation in obesity, T2D, and related disorders is presented, and the effect of inflammation on diabetic complications and on the relationship between T2DM and other pathologies.
Journal ArticleDOI
PPARγ activation in adipocytes is sufficient for systemic insulin sensitization
Shigeki Sugii,Peter Olson,Peter Olson,Dorothy D. Sears,Maziyar Saberi,Annette R. Atkins,Grant D. Barish,Suk Hyun Hong,Glenda L. Castro,Yun Qiang Yin,Michael C. Nelson,Michael C. Nelson,Gene Hsiao,David R. Greaves,Michael Downes,Ruth T. Yu,Jerrold M. Olefsky,Ronald M. Evans,Ronald M. Evans,Ronald M. Evans +19 more
TL;DR: It is found that selective activation of PPARγ in adipocytes, but not in macrophages, is sufficient for whole-body insulin sensitization equivalent to systemic TZD treatment, and a specific application for fat selective PParγ modulators in diabetic therapy is suggested.