J
Jerrold M. Olefsky
Researcher at University of California, San Diego
Publications - 606
Citations - 83310
Jerrold M. Olefsky is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Insulin & Insulin resistance. The author has an hindex of 143, co-authored 595 publications receiving 77356 citations. Previous affiliations of Jerrold M. Olefsky include University of Colorado Boulder & University of Michigan.
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Journal ArticleDOI
Biosynthetic human insulin and proinsulin have additive but not synergistic effects on total body glucose disposal.
Robert R. Revers,Robert R. Henry,L Schmeiser,Orville G. Kolterman,Robert M. Cohen,Arthur H. Rubenstein,Bruce H. Frank,John A Galloway,Jerrold M. Olefsky +8 more
TL;DR: Using either approach to predict the glucose disposal rates, insulin and proinsulin appeared to have additive effects on total body glucose disposal.
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Characterization of insulin-like growth factor (IGF) binding proteins and their role in modulating IGF-I action in BHK cells.
D Hsu,Jerrold M. Olefsky +1 more
TL;DR: These results demonstrate coordinate regulation of IGFBP by serum starvation and IGF-I, such that at low concentrations of insulin, cell surface binding protein increases whereas binding protein secretion decreases, and at high concentrations of IGF-i, IGFBP secretion increases and cell surface IGF- I receptor decreases.
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Adipocyte-specific Repression of PPAR-gamma by NCoR Contributes to Scleroderma Skin Fibrosis
Benjamin D. Korman,Roberta Goncalves Marangoni,Gabriel Lord,Jerrold M. Olefsky,Warren G. Tourtellotte,John Varga +5 more
TL;DR: The results implicate, for the first time, to the knowledge, deregulated NCoR/PPAR-γ pathways in SSc, and they support a role of adipocyte modulation of skin fibrosis.
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Inducible Nitric Oxide Synthase Deficiency in Myeloid Cells Does Not Prevent Diet-Induced Insulin Resistance
Min Lu,Pingping Li,Jan Pferdekamper,WuQiang Fan,Maziyar Saberi,Simon Schenk,Jerrold M. Olefsky +6 more
TL;DR: It is concluded that iNOS inhibition in tissues other than myeloid cells is responsible for the beneficial effects in obesity/insulin resistance.
Journal ArticleDOI
Low pH accelerates dissociation of receptor-bound insulin.
TL;DR: Results indicate that low pH reduced insulin binding affinity by accelerating the rate of insulin dissociation, and this is accompanied by a reduction in the rates of receptor-mediated insulin degradation.