J
Jerrold M. Olefsky
Researcher at University of California, San Diego
Publications - 606
Citations - 83310
Jerrold M. Olefsky is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Insulin & Insulin resistance. The author has an hindex of 143, co-authored 595 publications receiving 77356 citations. Previous affiliations of Jerrold M. Olefsky include University of Colorado Boulder & University of Michigan.
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Journal ArticleDOI
Quantification of plasma cholesterol and triglyceride levels in hypercholesterolemic subjects receiving ascorbic acid supplements.
TL;DR: There is the unexpected appearance of extra pre-beta bands on lipoprotein electrophoresis by the end of the ascorbic acid treatment period.
Journal ArticleDOI
Inverse Regulation of Inflammation and Mitochondrial Function in Adipose Tissue Defines Extreme Insulin Sensitivity in Morbidly Obese Patients
Mohammed Qatanani,Yejun Tan,Radu Dobrin,Danielle M. Greenawalt,Guanghui Hu,Wenqing Zhao,Jerrold M. Olefsky,Dorothy D. Sears,Lee M. Kaplan,Daniel M. Kemp +9 more
TL;DR: An unsupervised informatics analysis revealed that immune response and inflammation-related genes were significantly downregulated in the omental adipose tissue of obese individuals with extreme insulin sensitivity and, to a much lesser extent, in subcutaneous adipose tissues of insulin-sensitive patients.
Journal ArticleDOI
Phosphatidylinositol 3-kinase is necessary and sufficient for insulin-stimulated stress fiber breakdown.
Stuart S. Martin,David W. Rose,Alan R. Saltiel,Anke Klippel,Lewis T. Williams,Jerrold M. Olefsky +5 more
TL;DR: Activation of PI3-kinase is necessary and sufficient to stimulate actin rearrangement, indicating that PI3 -kinase may initiate the only signaling cascade required for insulin to induce cytoskeletal restructuring.
Journal ArticleDOI
p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity.
Bernat Baeza-Raja,Pingping Li,Natacha Le Moan,Benjamin D. Sachs,Benjamin D. Sachs,Christian Schachtrup,Christian Schachtrup,Dimitrios Davalos,Eirini Vagena,Dave Bridges,Choel Kim,Alan R. Saltiel,Jerrold M. Olefsky,Katerina Akassoglou +13 more
TL;DR: It is shown that the p75 neurotrophin receptor (p75NTR) is a regulator of glucose uptake and insulin resistance, and suggested that signaling from p75N TR to Rab5 family GTPases may represent a unique therapeutic target for insulin resistance and diabetes.