J
Jerrold M. Olefsky
Researcher at University of California, San Diego
Publications - 606
Citations - 83310
Jerrold M. Olefsky is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Insulin & Insulin resistance. The author has an hindex of 143, co-authored 595 publications receiving 77356 citations. Previous affiliations of Jerrold M. Olefsky include University of Colorado Boulder & University of Michigan.
Papers
More filters
Journal ArticleDOI
Inflamed fat: what starts the fire?
Jaap G. Neels,Jerrold M. Olefsky +1 more
TL;DR: The importance of C-C motif chemokine receptor 2 (CCR2) in macrophage recruitment to adipose tissue and the development of obesity and its complications is shown.
Journal ArticleDOI
PPARδ regulates glucose metabolism and insulin sensitivity
Chih-Hao Lee,Peter Olson,Peter Olson,Andrea L. Hevener,Isaac R. Mehl,Isaac R. Mehl,Ling Wa Chong,Jerrold M. Olefsky,Frank J. Gonzalez,Jungyeob Ham,Heonjoong Kang,Jeffrey M. Peters,Ronald M. Evans +12 more
TL;DR: It is shown that PPARδ (NR1C2) knockout mice are metabolically less active and glucose-intolerant, whereas receptor activation in db/db mice improves insulin sensitivity, and gene array and functional analyses suggest that PParδ ameliorates hyperglycemia by increasing glucose flux through the pentose phosphate pathway and enhancing fatty acid synthesis.
Journal ArticleDOI
Macrophage PPARγ is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones
Andrea L. Hevener,Jerrold M. Olefsky,Donna Reichart,M. T. Audrey Nguyen,Gautarn Bandyopadyhay,Ho-Yin Leung,Matthew J. Watt,Christopher Benner,Mark A. Febbraio,Anh-Khoi Nguyen,Brian Folian,Shankar Subramaniam,Frank J. Gonzalez,Christopher K. Glass,Mercedes Ricote +14 more
TL;DR: Findings reveal an essential role of PPAR gamma in macrophages for the maintenance of whole-body insulin action and in mediating the antidiabetic actions of TZDs.
Journal ArticleDOI
Metabolic Effects of New Oral Hypoglycemic Agent CS-045 in NIDDM Subjects
TL;DR: CS-045 improves insulin resistance, reduces insulinemia, lowers hepatic glucose production, and improves both fasting and postprandial glycemia in NIDDM subjects.
Journal ArticleDOI
A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1.
Tetsuro Haruta,Tatsuhito Uno,Junko Kawahara,Atsuko Takano,Katsuya Egawa,Prem M. Sharma,Jerrold M. Olefsky,Jerrold M. Olefsky,Masashi Kobayashi +8 more
TL;DR: Results indicate that insulin-induced serine/threonine phosphorylation and degradation of IRS-1 are mediated by a rapamycin-sensitive pathway, which is downstream of PI 3-kinase and independent of ras/MAP kinase.