J
Jerrold M. Olefsky
Researcher at University of California, San Diego
Publications - 606
Citations - 83310
Jerrold M. Olefsky is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Insulin & Insulin resistance. The author has an hindex of 143, co-authored 595 publications receiving 77356 citations. Previous affiliations of Jerrold M. Olefsky include University of Colorado Boulder & University of Michigan.
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Journal ArticleDOI
The Insulin Receptor: Its Role in Insulin Resistance of Obesity and Diabetes
TL;DR: The purpose of this review is to summarize current knowledge concerning the cellular mechanisms of insulin resistance in these conditions, with specific emphasis on insulin receptors and how they may relate to the pathogenesis of resistance to insulin action.
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An Integrated View of Immunometabolism
TL;DR: The major features of the current understanding with respect to chronic obesity-related inflammation in metabolic tissues are reviewed and how these inflammatory changes affect insulin sensitivity, insulin secretion, food intake, and glucose homeostasis are reviewed.
Journal ArticleDOI
Protein tyrosine phosphatase 1B interacts with the activated insulin receptor.
B L Seely,Patricia A. Staubs,Donna Reichart,Paulos Berhanu,Kim L. Milarski,Alan R. Saltiel,Jyotirmoy Kusari,Jerrold M. Olefsky +7 more
TL;DR: It is concluded that PTP1B can associate directly with the activated insulin receptor at multiple different phosphotyrosine sites and that dephosphorylation by PTP 1B may play a significant role in insulin receptor signal transduction.
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Profiling Gene Transcription In Vivo Reveals Adipose Tissue as an Immediate Target of Tumor Necrosis Factor-α Implications for Insulin Resistance
Hong Ruan,Philip D.G. Miles,Christine Ladd,Kenneth N. Ross,Todd R. Golub,Todd R. Golub,Jerrold M. Olefsky,Harvey F. Lodish +7 more
TL;DR: It is demonstrated that TNF-alpha antagonizes the actions of insulin, at least in part, through regulation of adipocyte gene expression including reduction in ACRP30 mRNA and induction of lipolysis resulting in increased plasma FFAs.
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Insulin action and resistance in obesity and noninsulin-dependent type II diabetes mellitus
TL;DR: In intact subjects with the use of the euglycemic glucose clamp technique, both insulin receptors and insulin-mediated glucose metabolism have been studied in adipocytes and monocytes from affected individuals, and more severe insulin resistance is due to the postreceptor lesion and is correctable with appropriate therapy.