J
Jerrold M. Olefsky
Researcher at University of California, San Diego
Publications - 606
Citations - 83310
Jerrold M. Olefsky is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Insulin & Insulin resistance. The author has an hindex of 143, co-authored 595 publications receiving 77356 citations. Previous affiliations of Jerrold M. Olefsky include University of Colorado Boulder & University of Michigan.
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Journal ArticleDOI
Fat Talks, Liver and Muscle Listen
TL;DR: Cao et al. (2008) take this concept a step further by identifying a fatty acid metabolite generated in adipose tissue that regulates insulin sensitivity in liver and muscle.
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Suppression of Egr‐1 transcription through targeting of the serum response factor by oncogenic H‐Ras
Soon Young Shin,Young Yil Bahk,Jesang Ko,Il-Yup Chung,Young Seek Lee,Julian Downward,Hermann Eibel,Prem M. Sharma,Jerrold M. Olefsky,Young Ho Kim,Bonghee Lee,Young Han Lee +11 more
TL;DR: The findings suggest a novel signaling mechanism by which prolonged activation of oncogenic H‐Ras can trigger the loss of tumor suppressor Egr‐1 through the PI3K pathway in NIH3T3 fibroblast model cell lines.
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Insulin activates p21Ras and guanine nucleotide releasing factor in cells expressing wild type and mutant insulin receptors.
TL;DR: Results indicated that p 21Ras.GTP is an important signaling molecule in insulin's mitogenic pathway, but may not participate in metabolic signaling and that insulin's stimulatory effects on p21Ras are mediated through Ras GRF.
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Adiposity, dyslipidemia, and insulin resistance in mice with targeted deletion of phospholipid scramblase 3 (PLSCR3).
Therese Wiedmer,Ji Zhao,Lilin Li,Quansheng Zhou,Andrea L. Hevener,Jerrold M. Olefsky,Linda K. Curtiss,Peter J. Sims +7 more
TL;DR: The data suggest that the expression of PLSCR3 may be required for normal adipocyte and/or macrophage maturation or function and raise the possibility that deletions or mutations affecting the PL SCR3(-/-) gene locus may contribute to the risk for lipid-related disorders in humans.
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The effect of ten days of fasting on various aspects of carbohydrate metabolism in obese diabetic subjects with significant fasting hyperglycemia.
TL;DR: The beneficial effects of the 10-day period of caloric deprivation were transitory and fasting plasma glucose values had returned to prefast levels in most patients within a few months.