J
Jerrold M. Olefsky
Researcher at University of California, San Diego
Publications - 606
Citations - 83310
Jerrold M. Olefsky is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Insulin & Insulin resistance. The author has an hindex of 143, co-authored 595 publications receiving 77356 citations. Previous affiliations of Jerrold M. Olefsky include University of Colorado Boulder & University of Michigan.
Papers
More filters
Journal ArticleDOI
Localization of the Insulin-like Growth Factor I Receptor Binding Sites for the SH2 Domain Proteins p85, Syp, and GTPase Activating Protein *
B. Lynn Seely,Donna Reichart,Patricia A. Staubs,Byung Hak Jhun,David S. Hsu,Hiroshi Maegawa,Kim L. Milarski,Alan R. Saltiel,Jerrold M. Olefsky +8 more
TL;DR: It is concluded that p85 and Syp may bind directly to the IGF-I receptor at tyrosine 1316, and that GAP may bind to the insulin-like growth factor I receptor in lysates of cells overexpressing the human IGF- I receptor.
Journal ArticleDOI
In Vivo Regulation of Non-Insulin-Mediated and Insulin-Mediated Glucose Uptake by Epinephrine*
TL;DR: EPI inhibits IMGU, but has no effect on NIMGU; when NIM GU is taken into account, EPI has a more potent ability to inhibit IMGU than previously found; and the systems responsible for NIMgu and IMGU are independently regulated.
Journal ArticleDOI
Association of the Insulin Receptor with Phospholipase C-γ (PLCγ) in 3T3-L1 Adipocytes Suggests a Role for PLCγ in Metabolic Signaling by Insulin
Ayse G. Kayali,Jens Eichhorn,Tetsuro Haruta,Aaron J. Morris,James G. Nelson,Peter Vollenweider,Jerrold M. Olefsky,Nicholas J. G. Webster +7 more
TL;DR: It is concluded that PLCγ is an active participant in metabolic and perhaps mitogenic signaling by the insulin receptor in 3T3-L1 adipocytes.
Journal ArticleDOI
Fetuin-A: the missing link in lipid-induced inflammation
TL;DR: The liver secretory protein fetuin-A (FetA) is shown to act as an adaptor protein between free fatty acids (FFAs) and Toll-like receptor 4 (TLR4) and provide the missing link between FFAs and chronic low-grade inflammation that impairs insulin sensitivity.
Journal ArticleDOI
Nerve growth factor processing and trafficking events following TrkA-mediated endocytosis.
TL;DR: The ability of 125I-NGF to remain receptor-associated during acidic conditions may provide a mechanism for its retroendocytosis via recycling TrkA vesicles.