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A. Mesut Erzurumluoglu
Researcher at University of Leicester
Publications - 41
Citations - 3627
A. Mesut Erzurumluoglu is an academic researcher from University of Leicester. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 18, co-authored 41 publications receiving 2352 citations. Previous affiliations of A. Mesut Erzurumluoglu include University of Bristol & Medical Research Council.
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Journal ArticleDOI
LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis
Jie Zheng,A. Mesut Erzurumluoglu,Benjamin Elsworth,John P. Kemp,Laurence J. Howe,Philip C Haycock,Gibran Hemani,Katherine E. Tansey,Charles Laurin,Early Genetics,Beate St Pourcain,Nicole M. Warrington,Hilary K. Finucane,Hilary K. Finucane,Alkes L. Price,Alkes L. Price,Brendan Bulik-Sullivan,Verneri Anttila,Lavinia Paternoster,Tom R. Gaunt,Tom R. Gaunt,David M. Evans,David M. Evans,Benjamin M. Neale,Benjamin M. Neale +24 more
TL;DR: The proposed LD Hub database and accompanying web interface will ensure maximal uptake of the LD score regression methodology, provide a useful database for the public dissemination of GWAS results, and provide a method for easily screening hundreds of traits for overlapping genetic aetiologies.
Journal ArticleDOI
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
Evangelos Evangelou,Evangelos Evangelou,Helen R. Warren,Helen R. Warren,David Mosen-Ansorena,Borbala Mifsud,Raha Pazoki,He Gao,Georgios Ntritsos,Niki Dimou,Claudia P. Cabrera,Claudia P. Cabrera,Ibrahim Karaman,Fu Liang Ng,Marina Evangelou,K. Witkowska,Evan Tzanis,Jacklyn N. Hellwege,Ayush Giri,Digna R. Velez Edwards,Yan V. Sun,Kelly Cho,Kelly Cho,J. Michael Gaziano,J. Michael Gaziano,Peter W.F. Wilson,Philip S. Tsao,Csaba P. Kovesdy,Tõnu Esko,Tõnu Esko,Reedik Mägi,Lili Milani,Peter Almgren,Thibaud Boutin,Stéphanie Debette,Jun Ding,Franco Giulianini,Elizabeth G. Holliday,Anne U. Jackson,Ruifang Li-Gao,Wei-Yu Lin,Jian'an Luan,Massimo Mangino,Massimo Mangino,Christopher Oldmeadow,Bram P. Prins,Yong Qian,Muralidharan Sargurupremraj,Nabi Shah,Nabi Shah,Praveen Surendran,Sébastien Thériault,Sébastien Thériault,Niek Verweij,Niek Verweij,Niek Verweij,Sara M. Willems,Jing Hua Zhao,Philippe Amouyel,John M. C. Connell,Renée de Mutsert,Alex S. F. Doney,Martin Farrall,Martin Farrall,Cristina Menni,Andrew D. Morris,Raymond Noordam,Guillaume Paré,Neil Poulter,Denis C. Shields,Alice Stanton,Simon Thom,Gonçalo R. Abecasis,Najaf Amin,Dan E. Arking,Kristin L. Ayers,Kristin L. Ayers,Caterina Barbieri,Chiara Batini,Joshua C. Bis,Tineka Blake,Murielle Bochud,Michael Boehnke,Eric Boerwinkle,Dorret I. Boomsma,Erwin P. Bottinger,Peter S. Braund,Peter S. Braund,Marco Brumat,Archie Campbell,Harry Campbell,Aravinda Chakravarti,John C. Chambers,Ganesh Chauhan,Marina Ciullo,Massimiliano Cocca,Francis S. Collins,Heather J. Cordell,Gail Davies,Martin H. de Borst,Eco J. C. de Geus,Ian J. Deary,Joris Deelen,Fabiola Del Greco M,Cumhur Y Demirkale,Marcus Dörr,Georg Ehret,Georg Ehret,Roberto Elosua,Stefan Enroth,A. Mesut Erzurumluoglu,Teresa Ferreira,Mattias Frånberg,Mattias Frånberg,Oscar H. Franco,Ilaria Gandin,Paolo Gasparini,Vilmantas Giedraitis,Christian Gieger,Giorgia Girotto,Anuj Goel,Anuj Goel,Alan J. Gow,Alan J. Gow,Vilmundur Gudnason,Xiuqing Guo,Ulf Gyllensten,Anders Hamsten,Tamara B. Harris,Sarah E. Harris,Catharina A. Hartman,Aki S. Havulinna,Aki S. Havulinna,Andrew A. Hicks,Edith Hofer,Albert Hofman,Albert Hofman,Jouke-Jan Hottenga,Jennifer E. Huffman,Jennifer E. Huffman,Shih-Jen Hwang,Erik Ingelsson,Erik Ingelsson,Alan James,Alan James,Rick Jansen,Marjo-Riitta Järvelin,Roby Joehanes,Åsa Johansson,Andrew D. Johnson,Peter K. Joshi,Pekka Jousilahti,J. Wouter Jukema,Antti Jula,Mika Kähönen,Sekar Kathiresan,Sekar Kathiresan,Sekar Kathiresan,Bernard Keavney,Bernard Keavney,Kay-Tee Khaw,Paul Knekt,Joanne Knight,Ivana Kolcic,Jaspal S. Kooner,Seppo Koskinen,Kati Kristiansson,Zoltán Kutalik,Zoltán Kutalik,Maris Laan,Marty Larson,Lenore J. Launer,Benjamin Lehne,Terho Lehtimäki,David C. Liewald,Li Lin,Lars Lind,Cecilia M. Lindgren,Cecilia M. Lindgren,Cecilia M. Lindgren,Yongmei Liu,Ruth J. F. Loos,Ruth J. F. Loos,Lorna M. Lopez,Lorna M. Lopez,Lorna M. Lopez,Yingchang Lu,Leo-Pekka Lyytikäinen,Anubha Mahajan,Chrysovalanto Mamasoula,Jaume Marrugat,Jonathan Marten,Yuri Milaneschi,Anna Morgan,Andrew P. Morris,Andrew P. Morris,Alanna C. Morrison,Peter J. Munson,Mike A. Nalls,Priyanka Nandakumar,Christopher P. Nelson,Christopher P. Nelson,Teemu J. Niiranen,Teemu J. Niiranen,Ilja M. Nolte,Teresa Nutile,Albertine J. Oldehinkel,Ben A. Oostra,Paul F. O'Reilly,Elin Org,Sandosh Padmanabhan,Sandosh Padmanabhan,Walter Palmas,Aarno Palotie,Aarno Palotie,Aarno Palotie,Alison Pattie,Brenda W.J.H. Penninx,Markus Perola,Markus Perola,Markus Perola,Annette Peters,Ozren Polasek,Peter P. Pramstaller,Quang Tri Nguyen,Olli T. Raitakari,Olli T. Raitakari,Meixia Ren,Rainer Rettig,Kenneth Rice,Paul M. Ridker,Paul M. Ridker,Janina S. Ried,Harriëtte Riese,Samuli Ripatti,Antonietta Robino,Lynda M. Rose,Jerome I. Rotter,Igor Rudan,Daniela Ruggiero,Yasaman Saba,Cinzia Sala,Veikko Salomaa,Nilesh J. Samani,Nilesh J. Samani,Antti-Pekka Sarin,Reinhold Schmidt,Helena Schmidt,Nick Shrine,David S. Siscovick,Albert V. Smith,Harold Snieder,Siim Sõber,Rossella Sorice,John M. Starr,David J. Stott,David P. Strachan,Rona J. Strawbridge,Johan Sundström,Morris A. Swertz,Kent D. Taylor,Alexander Teumer,Martin D. Tobin,Maciej Tomaszewski,Maciej Tomaszewski,Daniela Toniolo,Michela Traglia,Stella Trompet,Jaakko Tuomilehto,Christophe Tzourio,André G. Uitterlinden,Ahmad Vaez,Ahmad Vaez,Peter J. van der Most,Cornelia M. van Duijn,Anne-Claire Vergnaud,Germaine C. Verwoert,Veronique Vitart,Uwe Völker,Peter Vollenweider,Dragana Vuckovic,Dragana Vuckovic,Hugh Watkins,Hugh Watkins,Sarah H. Wild,Gonneke Willemsen,James F. Wilson,James F. Wilson,Alan F. Wright,Jie Yao,Tatijana Zemunik,Weihua Zhang,Weihua Zhang,John Attia,Adam S. Butterworth,Adam S. Butterworth,Daniel I. Chasman,Daniel I. Chasman,David Conen,David Conen,Francesco Cucca,Francesco Cucca,John Danesh,John Danesh,Caroline Hayward,Joanna M. M. Howson,Markku Laakso,Edward G. Lakatta,Claudia Langenberg,Olle Melander,Dennis O. Mook-Kanamori,Colin N. A. Palmer,Lorenz Risch,Robert A. Scott,Rodney J. Scott,Peter S. Sever,Tim D. Spector,Pim van der Harst,Nicholas J. Wareham,Eleftheria Zeggini,Daniel Levy,Patricia B. Munroe,Patricia B. Munroe,Christopher Newton-Cheh,Christopher Newton-Cheh,Morris J. Brown,Morris J. Brown,Andres Metspalu,Adriana M. Hung,Christopher J. O'Donnell,Todd L. Edwards,Bruce M. Psaty,Bruce M. Psaty,Ioanna Tzoulaki,Ioanna Tzoulaki,Michael R. Barnes,Michael R. Barnes,Louise V. Wain,Louise V. Wain,Paul Elliott,Mark J. Caulfield,Mark J. Caulfield +341 more
TL;DR: In this article, the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry was conducted.
Journal ArticleDOI
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries
Nick Shrine,Anna L. Guyatt,A. Mesut Erzurumluoglu,Victoria E. Jackson,Victoria E. Jackson,Victoria E. Jackson,Brian D. Hobbs,Carl A. Melbourne,Chiara Batini,Katherine A. Fawcett,Kijoung Song,Phuwanat Sakornsakolpat,Phuwanat Sakornsakolpat,Xingnan Li,Ruth Boxall,Nicola F. Reeve,Ma'en Obeidat,Jing Hua Zhao,Matthias Wielscher,Stefan Weiss,Katherine A. Kentistou,James P. Cook,Benjamin B. Sun,Jian Zhou,Jennie Hui,Stefan Karrasch,Medea Imboden,Sarah E. Harris,Jonathan Marten,Stefan Enroth,Shona M. Kerr,Ida Surakka,Vitart,Terho Lehtimäki,Richard J. Allen,Per Bakke,Terri H. Beaty,Eugene R. Bleecker,Yohan Bossé,Corry-Anke Brandsma,Zhengming Chen,James D. Crapo,John Danesh,Dawn L. DeMeo,Frank Dudbridge,Ralf Ewert,Christian Gieger,Amund Gulsvik,Anna Hansell,Ke Hao,Joshua D. Hoffman,John E. Hokanson,Georg Homuth,Peter K. Joshi,Philippe Joubert,Claudia Langenberg,Liming Li,Kuang Lin,Lars Lind,Nicholas Locantore,Jian'an Luan,Anubha Mahajan,Joseph C. Maranville,Alison Catherine Murray,David C. Nickle,Richard Packer,Margaret M. Parker,Megan L. Paynton,David J. Porteous,Dmitry Prokopenko,Dandi Qiao,Rajesh Rawal,Heiko Runz,Ian Sayers,Don D. Sin,Blair H. Smith,María Soler Artigas,David Sparrow,Ruth Tal-Singer,Timmers Prhj,van den Berge M,John C. Whittaker,Prescott G. Woodruff,Laura M Yerges Armstrong,Olga G. Troyanskaya,Olli T. Raitakari,Mika Kähönen,Ozren Polasek,Ozren Polasek,Ulf Gyllensten,Igor Rudan,Ian J. Deary,Nicole Probst-Hensch,Nicole Probst-Hensch,Holger Schulz,Alan James,Alan James,James F. Wilson,Beate Stubbe,Eleftheria Zeggini,Marjo-Riitta Järvelin,Nicholas J. Wareham,Edwin K. Silverman,Caroline Hayward,Andrew P. Morris,Andrew P. Morris,Adam S. Butterworth,Robert A. Scott,Robin G Walters,Deborah A. Meyers,Michael H. Cho,David P. Strachan,Ian P. Hall,Tobin,Louise V. Wain,Louise V. Wain +115 more
TL;DR: In this paper, a genome-wide association study in 400,102 individuals of European ancestry was conducted to define 279 lung function signals, 139 of which are new and the combined effect of these variants showed generalizability across smokers and never smokers, and across ancestral groups.
Journal ArticleDOI
Using human genetics to understand the disease impacts of testosterone in men and women
Katherine S. Ruth,Felix R. Day,Jessica Tyrrell,Deborah J. Thompson,Andrew R. Wood,Anubha Mahajan,Robin N Beaumont,Laura B. L. Wittemans,Laura B. L. Wittemans,Susan Martin,Alexander S Busch,Alexander S Busch,A. Mesut Erzurumluoglu,Benjamin Hollis,Tracy A. O'Mara,Mark I. McCarthy,Claudia Langenberg,Douglas F. Easton,Nicholas J. Wareham,Stephen Burgess,Anna Murray,Ken K. Ong,Ken K. Ong,Timothy M. Frayling,John R. B. Perry +24 more
TL;DR: Genetic analysis of data from over 400,000 participants in the UK Biobank Study shows that circulating testosterone levels have sex-specific implications for cardiometabolic diseases and cancer outcomes and the genetic determinants of testosterone levels are substantially different between sexes.
Journal ArticleDOI
Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets
Louise V. Wain,Louise V. Wain,Nick Shrine,María Soler Artigas,A. Mesut Erzurumluoglu,Boris Noyvert,Lara Bossini-Castillo,Ma'en Obeidat,Amanda P. Henry,Michael A. Portelli,Robert J. Hall,Charlotte K. Billington,Tracy L. Rimington,Anthony G. Fenech,Catherine John,Tineka Blake,Victoria E. Jackson,Richard J. Allen,Bram P. Prins,Archie Campbell,David J. Porteous,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Matthias Wielscher,Alan James,Alan James,Jennie Hui,Jennie Hui,Nicholas J. Wareham,Jing Hua Zhao,James F. Wilson,Peter K. Joshi,Beate Stubbe,Rajesh Rawal,Holger Schulz,Medea Imboden,Nicole Probst-Hensch,Stefan Karrasch,Christian Gieger,Ian J. Deary,Sarah E. Harris,Jonathan Marten,Igor Rudan,Stefan Enroth,Ulf Gyllensten,Shona M. Kerr,Ozren Polasek,Ozren Polasek,Mika Kähönen,Ida Surakka,Veronique Vitart,Caroline Hayward,Terho Lehtimäki,Olli T. Raitakari,David M. Evans,David M. Evans,A. John Henderson,Craig E. Pennell,Carol A. Wang,Peter D. Sly,Emily S. Wan,Robert Busch,Brian D. Hobbs,Augusto A. Litonjua,David Sparrow,Amund Gulsvik,Per Bakke,James D. Crapo,Terri H. Beaty,Nadia N. Hansel,Rasika A. Mathias,Ingo Ruczinski,Kathleen C. Barnes,Yohan Bossé,Philippe Joubert,Maarten van den Berge,Corry-Anke Brandsma,Peter D. Paré,Don D. Sin,David C. Nickle,Ke Hao,Omri Gottesman,Frederick E. Dewey,Shannon Bruse,David J. Carey,H. Lester Kirchner,Stefan Jonsson,Gudmar Thorleifsson,Ingileif Jonsdottir,Ingileif Jonsdottir,Thorarinn Gislason,Kari Stefansson,Kari Stefansson,Claudia Schurmann,Girish N. Nadkarni,Erwin P. Bottinger,Ruth J. F. Loos,Robin G. Walters,Zhengming Chen,Iona Y Millwood,Julien Vaucher,Om P Kurmi,Liming Li,Liming Li,Anna Hansell,Christopher E. Brightling,Christopher E. Brightling,Eleftheria Zeggini,Michael H. Cho,Edwin K. Silverman,Ian Sayers,Gosia Trynka,Andrew P. Morris,David P. Strachan,Ian P. Hall,Martin D. Tobin,Martin D. Tobin +116 more
TL;DR: In this article, a genetic risk score was associated with COPD susceptibility (odds ratio per 1 s.d. of the risk score (∼6 alleles) (95% confidence interval) = 1.24 (1.20-1.27), P = 5.05 × 10(-49)), and they observed a 3.7-fold difference in COPD risk between individuals in the highest and lowest GA risk score deciles in UK Biobank.