J
Jo Vandesompele
Researcher at Ghent University
Publications - 406
Citations - 67052
Jo Vandesompele is an academic researcher from Ghent University. The author has contributed to research in topics: Neuroblastoma & microRNA. The author has an hindex of 88, co-authored 383 publications receiving 59368 citations. Previous affiliations of Jo Vandesompele include Washington University in St. Louis & Ghent University Hospital.
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Journal ArticleDOI
Increased levels of systemic LPS-positive bacterial extracellular vesicles in patients with intestinal barrier dysfunction.
Joeri Tulkens,Glenn Vergauwen,Jan Van Deun,Edward Geeurickx,Bert Dhondt,Lien Lippens,Marie-Angélique De Scheerder,Ilkka Miinalainen,Pekka Rappu,Bruno G. De Geest,Katrien Vandecasteele,Debby Laukens,Linos Vandekerckhove,Hannelore Denys,Jo Vandesompele,Olivier De Wever,An Hendrix +16 more
TL;DR: Fractionated plasma of 49 subjects is fractionated to distinguish bacterial EV-associated LPS from other LPS products, which may deliver and elicit a variety of immunological and metabolic responses in different organs including the brain.
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RTPrimerDB: the portal for real-time PCR primers and probes
TL;DR: RTPrimerDB is a one-stop portal for high-quality and highly annotated real-time PCR assays and is available for download in the recently developed RDML format and as bulk export file.
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Quantification of splice variants using real-time PCR
TL;DR: A novel method for creating a reliable standard curve using one plasmid containing both alternative transcripts and an absolute standard curve based on a dilution series of fluorometrically quantified PCR products is described.
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An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours
Pieter Mestdagh,Erik Fredlund,Erik Fredlund,Filip Pattyn,Ali Rihani,T. Van Maerken,Joëlle Vermeulen,Candy Kumps,Björn Menten,K. De Preter,Alexander Schramm,Johannes H. Schulte,Rosa Noguera,Gudrun Schleiermacher,Isabelle Janoueix-Lerosey,Genevieve Laureys,R. Powel,David Nittner,J-C Marine,Markus Ringnér,Franki Speleman,Jo Vandesompele +21 more
TL;DR: For the first time, a T-UCR expression landscape in neuroblastoma is defined and widespread T- UCR involvement in diverse cellular processes that are deregulated in the process of tumourigenesis is suggested.
Journal ArticleDOI
MicroRNA miR-885-5p targets CDK2 and MCM5, activates p53 and inhibits proliferation and survival.
Elena A. Afanasyeva,Pieter Mestdagh,Candy Kumps,Jo Vandesompele,Volker Ehemann,Jessica Theissen,Matthias Fischer,Marc Zapatka,Benedikt Brors,Larissa Savelyeva,Vitaliya Sagulenko,Franki Speleman,Manfred Schwab,Frank Westermann +13 more
TL;DR: In this paper, the authors demonstrate that miR-885-5p is downregulated on loss of 3p25.3 region in neuroblastoma cells, leading to downregulation of cyclin-dependent kinase and mini-chromosome maintenance protein.