J
Jo Vandesompele
Researcher at Ghent University
Publications - 406
Citations - 67052
Jo Vandesompele is an academic researcher from Ghent University. The author has contributed to research in topics: Neuroblastoma & microRNA. The author has an hindex of 88, co-authored 383 publications receiving 59368 citations. Previous affiliations of Jo Vandesompele include Washington University in St. Louis & Ghent University Hospital.
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Journal ArticleDOI
RDML: structured language and reporting guidelines for real-time quantitative PCR data
Steve Lefever,Jan Hellemans,Filip Pattyn,Daniel R. Przybylski,Chris F. Taylor,René Geurts,Andreas Untergasser,Jo Vandesompele +7 more
TL;DR: Data related guidelines are proposed as a subset of the Minimum Information for Publication of Quantitative Real-Time PCR Experiments (MIQE) to guarantee inclusion of key data information when reporting experimental results.
Journal ArticleDOI
Genetic heterogeneity of neuroblastoma studied by comparative genomic hybridization
Jo Vandesompele,Nadine Van Roy,Mireille Van Gele,Genevieve Laureys,Peter F. Ambros,P. Heimann,Christine Devalck,Ed Schuuring,Penelope Brock,Jacques Otten,Jan Gyselinck,Anne De Paepe,Frank Speleman +12 more
TL;DR: The presence of 3p, 11q or 14q deletions defines a genetic subset of neuroblastomas and contributes to the further genetic characterization of stage 3 and 4 tumors without MYCN amplification (MNA) and 1p deletion.
Journal ArticleDOI
Impact of RNA quality on reference gene expression stability.
Claudina Perez-Novo,Cindy Claeys,Frank Speleman,Paul Van Cauwenberge,Claus Bachert,Jo Vandesompele +5 more
TL;DR: The objective of this study was to analyze the influence of RNA degradation on the stability and expression pattern of different internal control genes in patients with nasal polyposis and chronic rhinosinusitis.
Journal ArticleDOI
MYCN/c-MYC-induced microRNAs repress coding gene networks associated with poor outcome in MYCN/c-MYC-activated tumors
Pieter Mestdagh,Erik Fredlund,Filip Pattyn,Johannes H. Schulte,Daniel Muth,Joëlle Vermeulen,Candy Kumps,Stefanie Schlierf,K. De Preter,N. Van Roy,Rosa Noguera,Genevieve Laureys,Alexander Schramm,Angelika Eggert,Frank Westermann,Franki Speleman,Jo Vandesompele +16 more
TL;DR: A widespread correlation between miRNA activation and c-MYC/MYCN-mediated coding gene expression modulation is uncovered and further substantiate the overlapping functions of c- MYC and MYCN in the process of tumorigenesis.
Journal ArticleDOI
Prognostic Impact of Gene Expression–Based Classification for Neuroblastoma
André Oberthuer,Barbara Hero,Frank Berthold,Dilafruz Juraeva,Andreas Faldum,Yvonne Kahlert,Shahab Asgharzadeh,Robert C. Seeger,Paola Scaruffi,Gian Paolo Tonini,Isabelle Janoueix-Lerosey,Olivier Delattre,Gudrun Schleiermacher,Jo Vandesompele,Joëlle Vermeulen,Franki Speleman,Rosa Noguera,Marta Piqueras,Jean Bénard,Alexander Valent,Smadar Avigad,Isaac Yaniv,Axel Weber,Holger Christiansen,Richard Grundy,Katharina Schardt,Manfred Schwab,Roland Eils,Patrick Warnat,Lars Kaderali,Thorsten Simon,Boris Decarolis,Jessica Theissen,Frank Westermann,Benedikt Brors,Matthias Fischer +35 more
TL;DR: Gene expression-based classification using the 144-gene PAM predictor can contribute to improved treatment stratification of neuroblastoma patients.