J
Jo Vandesompele
Researcher at Ghent University
Publications - 406
Citations - 67052
Jo Vandesompele is an academic researcher from Ghent University. The author has contributed to research in topics: Neuroblastoma & microRNA. The author has an hindex of 88, co-authored 383 publications receiving 59368 citations. Previous affiliations of Jo Vandesompele include Washington University in St. Louis & Ghent University Hospital.
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Journal ArticleDOI
The cancer-associated microprotein CASIMO1 controls cell proliferation and interacts with squalene epoxidase modulating lipid droplet formation
Maria Polycarpou-Schwarz,Maria Polycarpou-Schwarz,Matthias Groß,Matthias Groß,Pieter Mestdagh,Johanna Schott,Stefanie Grund,Catherina Hildenbrand,Joachim Rom,Sebastian Aulmann,Hans-Peter Sinn,Jo Vandesompele,Sven Diederichs +12 more
TL;DR: Findings establish CASIMO1 as the first functional microprotein that plays a role in carcinogenesis and is implicated in the cell lipid homeostasis.
Journal ArticleDOI
Multicentre analysis of patterns of DNA gains and losses in 204 neuroblastoma tumors: How many genetic subgroups are there?
Jo Vandesompele,Frank Speleman,Nadine Van Roy,Genevieve Laureys,C. Brinkschmidt,Holger Christiansen,Fritz Lampert,Maria Lastowska,Nick Bown,Andrew D.J. Pearson,J.C. Nicholson,Fiona M. Ross,Valérie Combaret,Olivier Delattre,Bert G. Feuerstein,Dominique Plantaz +15 more
TL;DR: Analysis of comparative genomic hybridization (CGH) data of 120 tumors from four different studies, and data of 84 previously unpublishied tumors, allowed delineation of at least six different genetic subsets of neuroblastomas.
Journal ArticleDOI
miRBase Tracker: keeping track of microRNA annotation changes
Gert Van Peer,Steve Lefever,Jasper Anckaert,Anneleen Beckers,Ali Rihani,Alan Van Goethem,Pieter-Jan Volders,Fjoralba Zeka,Maté Ongenaert,Pieter Mestdagh,Jo Vandesompele +10 more
TL;DR: MiRBase Tracker is developed, an easy-to-use online database that keeps track of all historical and current miRNA annotation present in the miRBase database, and is expected to increase the transparency and annotation accuracy in the field of miRNA research.
Alternative Routes to Induce Na€ ive Pluripotency in Human Embryonic Stem Cells
Galbha Duggal,Sharat Warrier,Sabitri Ghimire,Dorien Broekaert,Margot Van der Jeught,Sylvie Lierman,Tom Deroo,Luc Peelman,Ann Van Soom,Ria Cornelissen,Pieter Mestdagh,Jo Vandesompele,Matthias S Roost,Roderick C. Slieker,Bastiaan T. H Eijmans,Dieter Deforce,Petra De Sutter,Susana Chuva De Sousa +17 more
TL;DR: In this article, a combination of small molecules and growth factors in culture medium (2i/LIF/basic fibroblast growth factor 1 Ascorbic acid 1 Forskolin) is reported to facilitate rapid induction of transgene-free na€ ive pluripotency in hESCs, as well as in mESCs.
Journal ArticleDOI
Accurate Outcome Prediction in Neuroblastoma across Independent Data Sets Using a Multigene Signature
Katleen De Preter,Joëlle Vermeulen,Benedikt Brors,Olivier Delattre,Angelika Eggert,Matthias Fischer,Isabelle Janoueix-Lerosey,Cinzia Lavarino,John M. Maris,Jaume Mora,Akira Nakagawara,André Oberthuer,Miki Ohira,Gudrun Schleiermacher,Alexander Schramm,Johannes H. Schulte,Qun Wang,Frank Westermann,Frank Speleman,Jo Vandesompele +19 more
TL;DR: The robustness and accuracy of the classifier enables prospective assessment of neuroblastoma patient outcome and might be an example for development and validation of robust gene expression signatures in other cancer entities.