J
Jo Vandesompele
Researcher at Ghent University
Publications - 406
Citations - 67052
Jo Vandesompele is an academic researcher from Ghent University. The author has contributed to research in topics: Neuroblastoma & microRNA. The author has an hindex of 88, co-authored 383 publications receiving 59368 citations. Previous affiliations of Jo Vandesompele include Washington University in St. Louis & Ghent University Hospital.
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Journal ArticleDOI
Revised risk estimation and treatment stratification of low- and intermediate-risk neuroblastoma patients by integrating clinical and molecular prognostic markers
André Oberthuer,Dilafruz Juraeva,Barbara Hero,Ruth Volland,Carolina Sterz,Rene Schmidt,Andreas Faldum,Yvonne Kahlert,Anne Engesser,Shahab Asgharzadeh,Robert C. Seeger,Miki Ohira,Akira Nakagawara,Paola Scaruffi,Gian Paolo Tonini,Isabelle Janoueix-Lerosey,Olivier Delattre,Gudrun Schleiermacher,Jo Vandesompele,Franki Speleman,Rosa Noguera,Marta Piqueras,Jean Bénard,Alexander Valent,Smadar Avigad,Isaac Yaniv,Richard Grundy,Monika Ortmann,Chunxuan Shao,Manfred Schwab,Roland Eils,Thorsten Simon,Jessica Theissen,Frank Berthold,Frank Westermann,Benedikt Brors,Matthias Fischer +36 more
TL;DR: Combination of gene expression–based classification and established prognostic markers improves risk estimation of patients with low-risk/intermediate-risk neuroblastoma.
Cancer-associated adipose tissue promotes breast cancer progression by paracrine Oncostatin M and JAK3/STAT3 signaling
Lore Lapeire,An Hendrix,Kathleen Lambein,Mieke Van Bockstal,Geert Braems,Rudy Van den Broecke,Ridha Limame,Pieter Mestdagh,Jo Vandesompele,Christian Vanhove,Dawn M. Maynard,Catherine Muller,Philippe Valet,Christian Gespach,Veronique Cocquyt,Marc Bracke,Hannelore Denys,Olivier De Wever +17 more
TL;DR: In this article, a combination of techniques, including transcriptomics, proteomics, and kinomics enabled them to identify paracrine secretion of oncostatin M (OSM) by cancer-associated adipose tissue.
Journal ArticleDOI
Chromosomal and microRNA expression patterns reveal biologically distinct subgroups of 11q- neuroblastoma.
Patrick G. Buckley,Leah Alcock,Kenneth Bryan,Isabella Bray,Johannes H. Schulte,Alexander Schramm,Angelika Eggert,Pieter Mestdagh,Katleen De Preter,Jo Vandesompele,Franki Speleman,Raymond L. Stallings +11 more
TL;DR: A miRNA expression signature, combined with an analysis of segmental imbalances, provides greater prediction of event-free survival and overall survival outcomes than 11q status by itself, improving patient stratification.
Journal Article
A mechanistic classification of clinical phenotypes in neuroblastoma
Sandra Ackermann,Maria Cartolano,Barbara Hero,Andrea Roderwieser,Christoph Bartenhagen,Carolina Rosswog,F Hertwig,Thorsten Simon,Angelika Eggert,Franki Speleman,Reinhard Buettner,Roderick J. O’Sullivan,Roman K. Thomas,Frank Berthold,Jo Vandesompele,Alexander Schramm,Frank Westermann,Johannes H. Schulte,Martin Peifer,M Fischer +19 more
TL;DR: Ackermann et al. as mentioned in this paper performed genome sequencing on 416 pretreatment neuroblastomas and assessed telomere maintenance mechanisms in 208 of these tumors, and found that patients with tumors that lacked telomeres maintenance mechanisms had an excellent prognosis, whereas the prognosis of patients whose tumors harbored a worse prognosis.
Journal ArticleDOI
Closing the circle: current state and perspectives of circular RNA databases.
TL;DR: A comprehensive overview of the current circRNA databases and their content, features, and usability is presented and important suggestions to streamline further research in this growing field are presented.