J
Jo Vandesompele
Researcher at Ghent University
Publications - 406
Citations - 67052
Jo Vandesompele is an academic researcher from Ghent University. The author has contributed to research in topics: Neuroblastoma & microRNA. The author has an hindex of 88, co-authored 383 publications receiving 59368 citations. Previous affiliations of Jo Vandesompele include Washington University in St. Louis & Ghent University Hospital.
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Journal ArticleDOI
Accurate RT-qPCR gene expression analysis on cell culture lysates.
TL;DR: An approach in which cDNA synthesis is carried out on crude cell lysates instead of on purified RNA samples can offer a fast and straightforward alternative to the classic workflow of RNA purification and c DNA synthesis.
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Neuroblastoma epigenetics: from candidate gene approaches to genome-wide screenings
TL;DR: This review gives an extensive overview of all epigenetic changes described in NB as of today, with a main focus on both prognostic use and the potential of genome-wide techniques to find epigenetic prognostic biomarkers in NB.
Journal ArticleDOI
Combined M-FISH and CGH analysis allows comprehensive description of genetic alterations in neuroblastoma cell lines.
Nadine Van Roy,Heidi Van Limbergen,Jo Vandesompele,Mireille Van Gele,Bruce Poppe,Helen R. Salwen,Genevieve Laureys,Nunes Manoel,Anne De Paepe,Frank Speleman +9 more
TL;DR: It is shown that a combination of M‐FISH with banding analysis, standard FISH, and CGH allowed a detailed description of the genetic alterations in 16 neuroblastoma cell lines and the ATBF1 gene, an AT‐binding transcription factor involved in normal neurogenesis, was shown to be present in the amplicon.
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The transcriptome of lung tumor-infiltrating dendritic cells reveals a tumor-supporting phenotype and a microRNA signature with negative impact on clinical outcome
Lotte Pyfferoen,Elisabeth Brabants,Celine Everaert,Nancy De Cabooter,Kelly Heyns,Kim Deswarte,Manon Vanheerswynghels,Sofie De Prijck,Glenn Waegemans,Melissa Dullaers,Hamida Hammad,Olivier De Wever,Pieter Mestdagh,Jo Vandesompele,Bart N. Lambrecht,Karim Vermaelen +15 more
TL;DR: In this paper, the authors used an orthotopic preclinical model of lung cancer to dissect how the lung tumor micro-environment affects tissue-resident Dendritic cells (DCs) and extract novel biologically and clinically relevant information.
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A constitutional translocation t(1;17)(p36.2;q11.2) in a neuroblastoma patient disrupts the human NBPF1 and ACCN1 genes.
Karl Vandepoele,Vanessa Andries,Nadine Van Roy,Katrien Staes,Jo Vandesompele,Genevieve Laureys,Els De Smet,Geert Berx,Franki Speleman,Frans van Roy +9 more
TL;DR: Cl cloning of both translocation breakpoints and the identification of a novel gene that is disrupted by this translocation are reported, indicating a role for the NBPF genes and for ACCN1 in tumor aggressiveness.