J
Jo Vandesompele
Researcher at Ghent University
Publications - 406
Citations - 67052
Jo Vandesompele is an academic researcher from Ghent University. The author has contributed to research in topics: Neuroblastoma & microRNA. The author has an hindex of 88, co-authored 383 publications receiving 59368 citations. Previous affiliations of Jo Vandesompele include Washington University in St. Louis & Ghent University Hospital.
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Journal ArticleDOI
Long noncoding RNA expression profiling in cancer: Challenges and opportunities.
Lucia Lorenzi,Francisco Avila Cobos,Anneleen Decock,Celine Everaert,Hetty Helsmoortel,Steve Lefever,Karen Verboom,Pieter-Jan Volders,Franki Speleman,Jo Vandesompele,Pieter Mestdagh +10 more
TL;DR: The challenges related to long noncoding RNA expression profiling are discussed, how cancer longnoncoding RNAs provide new opportunities for cancer diagnosis and treatment are highlighted, and future developments are reflected.
Journal ArticleDOI
Comprehensive NF1 screening on cultured Schwann cells from neurofibromas.
Ophélia Maertens,Hilde Brems,Jo Vandesompele,Thomas De Raedt,Ine Heyns,Thorsten Rosenbaum,Sofie De Schepper,Anne De Paepe,Geert Mortier,Sandra Janssens,Franki Speleman,Eric Legius,Ludwine Messiaen,Ludwine Messiaen +13 more
TL;DR: It is shown that two inactivating NF1 mutations, in a subpopulation of the Schwann cells, are required for neurofibroma formation in NF1 tumorigenesis, and differences in somatic inactivation mechanism might exist between NF1 microdeletion patients and the general NF1 population.
Journal ArticleDOI
Identification of miR-145 as a key regulator of the pigmentary process
Peter Dynoodt,Pieter Mestdagh,Gert Van Peer,Jo Vandesompele,Karen Goossens,Luc Peelman,Barbara Geusens,Reinhart Speeckaert,Jo Lambert,Mireille Van Gele +9 more
TL;DR: An miRNA signature associated with forskolin and ssUV treatment is established and the significant down- or upregulation of major pigmentation genes, after modulating miR-145 expression, suggests a key role for mi R-145 in regulating melanogenesis.
Journal ArticleDOI
MiR-137 functions as a tumor suppressor in neuroblastoma by downregulating KDM1A.
Kristina Althoff,Anneleen Beckers,Andrea Odersky,Pieter Mestdagh,Johannes Köster,Johannes Köster,Isabella Bray,Isabella Bray,Kenneth Bryan,Kenneth Bryan,Jo Vandesompele,Frank Speleman,Raymond L. Stallings,Raymond L. Stallings,Alexander Schramm,Angelika Eggert,Annika Sprüssel,Johannes H. Schulte,Johannes H. Schulte +18 more
TL;DR: It is concluded that miR‐137 directly targets KDM1A mRNA in neuroblastoma cells, and activates cell properties consistent with tumor suppression, and Therapeutic strategies to re‐express miR•137 in neuro Blastoma could be useful to reduce tumor aggressiveness.
Journal ArticleDOI
Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma.
Presha Rajbhandari,Gonzalo Lopez,Gonzalo Lopez,Claudia Capdevila,Beatrice Salvatori,Jiyang Yu,Jiyang Yu,Ruth Rodriguez-Barrueco,Ruth Rodriguez-Barrueco,Daniel Martinez,Mark Yarmarkovich,Nina Weichert-Leahey,Brian J. Abraham,Mariano J. Alvarez,Archana Iyer,Jo Lynne Harenza,Derek A. Oldridge,Katleen De Preter,Jan Koster,Shahab Asgharzadeh,Shahab Asgharzadeh,Robert C. Seeger,Robert C. Seeger,Jun Wei,Javed Khan,Jo Vandesompele,Pieter Mestdagh,Rogier Versteeg,A. Thomas Look,Richard A. Young,Antonio Iavarone,Anna Lasorella,Jose Silva,John M. Maris,John M. Maris,Andrea Califano +35 more
TL;DR: A framework to determine the downstream effectors of the genetic alterations sustaining neuroblastoma subtypes is presented, which can be easily extended to other tumor types, and nominates TEAD4 as a novel candidate for therapeutic intervention.