J
Jo Vandesompele
Researcher at Ghent University
Publications - 406
Citations - 67052
Jo Vandesompele is an academic researcher from Ghent University. The author has contributed to research in topics: Neuroblastoma & microRNA. The author has an hindex of 88, co-authored 383 publications receiving 59368 citations. Previous affiliations of Jo Vandesompele include Washington University in St. Louis & Ghent University Hospital.
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Journal ArticleDOI
Charting Extracellular Transcriptomes in The Human Biofluid RNA Atlas.
Eva Hulstaert,Eva Hulstaert,Annelien Morlion,Francisco Avila Cobos,Kimberly Verniers,Justine Nuytens,Eveline Vanden Eynde,Nurten Yigit,Jasper Anckaert,Anja Geerts,Pieter Hindryckx,Peggy Jacques,Peggy Jacques,Guy Brusselle,Ken R. Bracke,Tania Maes,Thomas Malfait,Thierry Derveaux,Virginie Ninclaus,Caroline Van Cauwenbergh,Kristien Roelens,Ellen Roets,Dimitri Hemelsoet,Kelly Tilleman,Lieve Brochez,Lieve Brochez,Scott Kuersten,Lukas M. Simon,Sebastian Karg,Alexandra Kautzky-Willers,Michael Leutner,Christa Nöhammer,Ondrej Slaby,Roméo Willinge Prins,Jan Koster,Steve Lefever,Gary P. Schroth,Jo Vandesompele,Pieter Mestdagh +38 more
TL;DR: In this paper, an atlas of messenger, circular, and small RNA transcriptomes of a comprehensive collection of 20 human biofluids is presented, which enables an informed selection of the most relevant biofluid to monitor particular diseases.
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Pharmacologic activation of wild-type p53 by nutlin therapy in childhood cancer
TL;DR: The preclinical data that support the potential therapeutic use of nutlin drugs in the treatment of various pediatric tumors are reviewed, including neuroblastoma, retinoblastoma, osteosarcoma, Ewing's sarcomA, rhabdomyosar coma, medulloblastomas, and childhood acute lymphoblastic leukemia.
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A dual fluorescent multiprobe assay for prion protein genotyping in sheep.
TL;DR: The development and validation of a robust, reliable and reproducible method for PRNP genotyping of a few to many sheep samples in a fast, simple and cost-effective way, applicable in standard equipped molecular genetic laboratories is reported.
Journal ArticleDOI
methBLAST and methPrimerDB: web-tools for PCR based methylation analysis.
Filip Pattyn,Jasmien Hoebeeck,Piet Robbrecht,Evi Michels,Anne De Paepe,Guy Bottu,David Coornaert,Robert Herzog,Frank Speleman,Jo Vandesompele +9 more
TL;DR: M methBLAST allows in silico assessment of primer specificity in PCR based methylation Assays that can be stored in the methPrimerDB database, which provides a search portal for validated methylation assays.
Journal ArticleDOI
Vapor nanobubble is the more reliable photothermal mechanism for inducing endosomal escape of siRNA without disturbing cell homeostasis
Juan C. Fraire,Gaëlle Houthaeve,Jing Liu,Laurens Raes,Lotte Vermeulen,Stephan Stremersch,Toon Brans,Gerardo García-Díaz Barriga,Sarah De Keulenaer,Filip Van Nieuwerburgh,Riet De Rycke,Jo Vandesompele,Pieter Mestdagh,Koen Raemdonck,Winnok H. De Vos,Stefaan C. De Smedt,Kevin Braeckmans,Kevin Braeckmans +17 more
TL;DR: VNBs are found to be more consistent to induce efficient endosomal escape and gene silencing independent of the cell type without long lasting effects on cell homeostasis.