J
Johannes H. de Winde
Researcher at Leiden University
Publications - 81
Citations - 7358
Johannes H. de Winde is an academic researcher from Leiden University. The author has contributed to research in topics: Saccharomyces cerevisiae & Pseudomonas putida. The author has an hindex of 42, co-authored 79 publications receiving 6845 citations. Previous affiliations of Johannes H. de Winde include Delft University of Technology & Darmstadt University of Applied Sciences.
Papers
More filters
Journal ArticleDOI
Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88
Herman Jan Pel,Johannes H. de Winde,Johannes H. de Winde,David B. Archer,Paul S. Dyer,Gerald Hofmann,Peter J. Schaap,Geoffrey Turner,Ronald P. de Vries,Richard Albang,Kaj Albermann,Mikael Rørdam Andersen,Jannick Dyrløv Bendtsen,Jacques A.E. Benen,Marco A. van den Berg,Stefaan Breestraat,Mark X. Caddick,Roland Contreras,Michael Cornell,Pedro M. Coutinho,Etienne Danchin,Alfons J. M. Debets,Peter J. T. Dekker,Piet W.M. van Dijck,Alard Van Dijk,Lubbert Dijkhuizen,Arnold J. M. Driessen,Christophe d'Enfert,Steven Geysens,Coenie Goosen,Gert S.P. Groot,Piet W. J. de Groot,Thomas Guillemette,Bernard Henrissat,Marga Herweijer,Johannes Petrus Theodorus Wilhelmus Van Den Hombergh,Cees A. M. J. J. van den Hondel,René T. J. M. van der Heijden,Rachel M. van der Kaaij,Frans M. Klis,Harrie J. Kools,Christian P. Kubicek,Patricia Ann van Kuyk,Jürgen Lauber,Xin Lu,Marc J. E. C. van der Maarel,Rogier Meulenberg,Hildegard Henna Menke,Martin Mortimer,Jens Nielsen,Stephen G. Oliver,Maurien M.A. Olsthoorn,K. Pal,K. Pal,Noël Nicolaas Maria Elisabeth Van Peij,Arthur F. J. Ram,Ursula Rinas,Johannes Andries Roubos,Cornelis Maria Jacobus Sagt,Monika Schmoll,Jibin Sun,David W. Ussery,János Varga,Wouter Vervecken,Peter J.J. Van De Vondervoort,Holger Wedler,Han A. B. Wösten,An-Ping Zeng,Albert J. J. van Ooyen,Jaap Visser,Hein Stam +70 more
TL;DR: The filamentous fungus Aspergillus niger is widely exploited by the fermentation industry for the production of enzymes and organic acids, particularly citric acid, and the sequenced genome revealed a large number of major facilitator superfamily transporters and fungal zinc binuclear cluster transcription factors.
Journal ArticleDOI
A Saccharomyces cerevisiae G-protein coupled receptor, Gpr1, is specifically required for glucose activation of the cAMP pathway during the transition to growth on glucose.
L. Kraakman,Katleen Lemaire,Pingsheng Ma,Aloys Teunissen,M. Donaton,Patrick Van Dijck,Joris Winderickx,Johannes H. de Winde,Johan M. Thevelein +8 more
TL;DR: It is shown that the G‐protein coupled receptor Gpr1 interacts with Gpa2 and is required for stimulation of cAMP synthesis by glucose, which appears to be the first example of a GPCR system activated by a nutrient in eukaryotic cells, suggesting a subfamily of GPCRs might be involved in nutrient sensing.
Journal ArticleDOI
The Genome-wide Transcriptional Responses of Saccharomyces cerevisiae Grown on Glucose in Aerobic Chemostat Cultures Limited for Carbon, Nitrogen, Phosphorus, or Sulfur
Viktor Marius Boer,Johannes H. de Winde,Johannes H. de Winde,Jack T. Pronk,Matthew D.W. Piper +4 more
TL;DR: The specific transcriptional responses of Saccharomyces cerevisiaeto growth limitation by carbon, nitrogen, phosphorus, or sulfur were characterized and functional annotations of these genes indicated cellular metabolism was altered to meet the growth requirements for nutrient-limited growth.
Journal ArticleDOI
Involvement of distinct G-proteins, Gpa2 and Ras, in glucose- and intracellular acidification-induced cAMP signalling in the yeast Saccharomyces cerevisiae.
Sonia Colombo,Pingsheng Ma,Liesbet Cauwenberg,Joris Winderickx,Marion Crauwels,Aloys Teunissen,David Nauwelaers,Johannes H. de Winde,Marie-Françoise Gorwa,Didier Colavizza,Johan M. Thevelein +10 more
TL;DR: It is suggested that intracellular acidification stimulates cAMP synthesis in vivo at least through activation of the Ras proteins, while glucose acts through the Gpa2 protein, which confers the typical phenotype associated with a reduced cAMP level.
Journal ArticleDOI
Role of transcriptional regulation in controlling fluxes in central carbon metabolism of Saccharomyces cerevisiae. A chemostat culture study.
Pascale Daran-Lapujade,Mickel L. A. Jansen,Jean-Marc Daran,Walter M. van Gulik,Johannes H. de Winde,Johannes H. de Winde,Jack T. Pronk +6 more
TL;DR: Results indicate that in vivo fluxes in the central carbon metabolism of S. cerevisiae grown in steadystate, carbon-limited chemostat cultures are controlled to a large extent via post-transcriptional mechanisms.