Jon Clardy

TL;DR: A protocol that combines computer modeling with anisotropic NMR data acquired using gel-aligned samples holds strong promise as an effective alternative means of assigning three-dimensional (3D) molecular structures and can provide an unequivocal and unbiased confirmation of interatomic connectivity and relative configuration for organic and natural product structures.

TL;DR: Understanding the role that long-chain N-acyl amino acids play in soil microbial communities should now be feasible with the identification of a cultured organism that has the genetic capacity to produce these compounds.

TL;DR: In this article, two synthetic approaches to a new indolocarbazole antitumor antibiotic, rebeccamycin, were developed and the absolute configuration was determined by a total synthesis.

TL;DR: This work shows that the P. luminescens pathogenic variant (P form) switches to a smaller-cell variant (M form) to initiate mutualism in host nematode intestines, which armed these nematodes for the next cycle of insect infection.

TL;DR: Small molecules known to be crucial for virulence and antibiosis in addition to previously unknown metabolites are dramatically upregulated by L-proline, linking the recognition of host environment to bacterial metabolic regulation.