J
Jon Clardy
Researcher at Harvard University
Publications - 990
Citations - 62414
Jon Clardy is an academic researcher from Harvard University. The author has contributed to research in topics: Absolute configuration & Bacteria. The author has an hindex of 116, co-authored 983 publications receiving 56617 citations. Previous affiliations of Jon Clardy include Howard Hughes Medical Institute & University of Chicago.
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Total synthesis of the macrolide antibiotic cytovaricin
TL;DR: A convergent asymmetric synthesis of the antinoeplastic macrolide antibiotic cytovaricin has been achieved through the synthesis and coupling of the illustrated spiroketal and polyol glycoside subunits.
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The evolution of gene collectives: How natural selection drives chemical innovation
TL;DR: It is suggested that biosynthetic gene clusters from microbes are ideal candidates for the evolutionary study of gene collectives; these selfish genetic elements evolve rapidly, they usually comprise a complete pathway, and they have a phenotype—a small molecule—that is easy to identify and assay.
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The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis
Rebecca A. Butcher,Frank C. Schroeder,Michael A. Fischbach,Paul D. Straight,Roberto Kolter,Christopher T. Walsh,Jon Clardy +6 more
TL;DR: kX gene cluster in Bacillus subtilis encodes an unusual hybrid polyketide/nonribosomal peptide synthase that has been linked to the production of the uncharacterized antibiotic bacillaene, which is a linear molecule with two amide bonds.
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Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes
Cindy R. Sinars,Joyce Cheung-Flynn,Ronald A. Rimerman,Jonathan G. Scammell,David F. Smith,Jon Clardy +5 more
TL;DR: This structure of a multi-FKBP domain protein clarifies the arrangement of these domains and their possible interactions with other proteins, and reports here the x-ray structures of human and squirrel monkey FKBP51, to 2.7 Å.