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Jon Clardy

Researcher at Harvard University

Publications -  990
Citations -  62414

Jon Clardy is an academic researcher from Harvard University. The author has contributed to research in topics: Absolute configuration & Bacteria. The author has an hindex of 116, co-authored 983 publications receiving 56617 citations. Previous affiliations of Jon Clardy include Howard Hughes Medical Institute & University of Chicago.

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Renierone, an antimicrobial metabolite from a marine sponge

TL;DR: The major antibacterial metabolite in the sponge Reniera sp. was shown to be an isoquinoline quinone, renierone (1 ), which was defined by X-ray crystallography as discussed by the authors.
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Colorimetric High-Throughput Screen for Detection of Heme Crystallization Inhibitors

TL;DR: The development of a 384-well microtiter plate screen to detect small molecules that can also disrupt heme crystallization is described, which requires no parasites or parasite-derived reagents and no radioactive materials and is suitable for a high-throughput screening platform.
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Discovery of 3-Formyl-Tyrosine Metabolites from Pseudoalteromonas tunicata through Heterologous Expression

TL;DR: In this article, sequence based searching for homologues of DdaF, the ATP-grasp amide ligase from dapdiamide biosynthesis, led to the identification of a previously unannotated biosynthetic gene cluster in Pseudoalteromonas tunicata.
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Studies on a biomimetic approach to aerothionin and psammaplysin-A

TL;DR: Oxidation of a plausible biological precursor for the spirocyclic systems of aerothionin and psammaplysin-A is described.
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Δ 9(15) -Africanene, a new sesquiterpene hydrocarbon from the soft coral Sinularia erecta

TL;DR: In this paper, the isolation and structural elucidation of Δ9(15)-africanene from the soft coralSinularia erecta is presented, which is the most closely related to our work.