J
Jon Clardy
Researcher at Harvard University
Publications - 990
Citations - 62414
Jon Clardy is an academic researcher from Harvard University. The author has contributed to research in topics: Absolute configuration & Bacteria. The author has an hindex of 116, co-authored 983 publications receiving 56617 citations. Previous affiliations of Jon Clardy include Howard Hughes Medical Institute & University of Chicago.
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Renierone, an antimicrobial metabolite from a marine sponge
TL;DR: The major antibacterial metabolite in the sponge Reniera sp. was shown to be an isoquinoline quinone, renierone (1 ), which was defined by X-ray crystallography as discussed by the authors.
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Colorimetric High-Throughput Screen for Detection of Heme Crystallization Inhibitors
Margaret A. Rush,Mary Lynn Baniecki,Ralph Mazitschek,Joseph F. Cortese,Roger C. Wiegand,Jon Clardy,Dyann F. Wirth +6 more
TL;DR: The development of a 384-well microtiter plate screen to detect small molecules that can also disrupt heme crystallization is described, which requires no parasites or parasite-derived reagents and no radioactive materials and is suitable for a high-throughput screening platform.
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Discovery of 3-Formyl-Tyrosine Metabolites from Pseudoalteromonas tunicata through Heterologous Expression
Leah C. Blasiak,Jon Clardy +1 more
TL;DR: In this article, sequence based searching for homologues of DdaF, the ATP-grasp amide ligase from dapdiamide biosynthesis, led to the identification of a previously unannotated biosynthetic gene cluster in Pseudoalteromonas tunicata.
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Studies on a biomimetic approach to aerothionin and psammaplysin-A
Kelvin T. Okamoto,Jon Clardy +1 more
TL;DR: Oxidation of a plausible biological precursor for the spirocyclic systems of aerothionin and psammaplysin-A is described.
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Δ 9(15) -Africanene, a new sesquiterpene hydrocarbon from the soft coral Sinularia erecta
Y. Kashman,Y. Kashman,M. Bodner,M. Bodner,Janet Finer-Moore,Janet Finer-Moore,Jon Clardy,Jon Clardy +7 more
TL;DR: In this paper, the isolation and structural elucidation of Δ9(15)-africanene from the soft coralSinularia erecta is presented, which is the most closely related to our work.