J
Jon Clardy
Researcher at Harvard University
Publications - 990
Citations - 62414
Jon Clardy is an academic researcher from Harvard University. The author has contributed to research in topics: Absolute configuration & Bacteria. The author has an hindex of 116, co-authored 983 publications receiving 56617 citations. Previous affiliations of Jon Clardy include Howard Hughes Medical Institute & University of Chicago.
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1,2,3,4,6-Penta-O-galloyl-β-D-glucopyranose inhibits angiogenesis via inhibition of capillary morphogenesis gene 2.
Lorna M. Cryan,Lauren Bazinet,Kaiane A. Habeshian,Shugeng Cao,Jon Clardy,Kenneth A. Christensen,Michael S. Rogers +6 more
TL;DR: It is found that PGG inhibits CMG2 with a submicromolar IC50 and it also inhibits the migration of human dermal microvascular endothelial cells at similar concentrations in vitro, suggesting that a portion of the in vivo antitumor activity of PGG may be the result of antiangiogenic activity mediated by inhibition of CMG 2.
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Luteone, a twenty three carbon terpenoid from the dorid nudi branch Cadlina luteomarginata
TL;DR: The structure of luteone, a twenty three carbon terpenoid, has been solved by performing a single crystal x-ray analysis on a 3,4-dinitrophenylhydrazone derivative as discussed by the authors.
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Synthesis and electronic properties of 2a,8b-dihydrocyclopent[cd]azulenes (elassovalenes)
Leo A. Paquette,C. C. Liao,Richard L. Burson,Robert E. Wingard,C. N. Shih,Jose Fayos,Jon Clardy +6 more
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Natural products: Beyond grind and find
Scott J. Miller,Jon Clardy +1 more
TL;DR: Chemists are able to synthesize, and deduce the structure of, ever more complex molecules produced by nature, but what does the future hold for this venerable field, and what are the new challenges?
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Structure of the spiroketal-macrolide ossamycin
Herbert A. Kirst,Jon S. Mynderse,James W. Martin,Patrick J. Baker,Jonathan W. Paschal,Jorge Rios Steiner,Emil B. Lobkovsky,Jon Clardy +7 more
TL;DR: The overall structure and relative stereochemistry of ossamycin have now been determined by single crystal X-ray diffraction studies, and absolute stereochemistry was established according to the previously determined configuration of its aminosaccharide constituent, ossamine.