J
Jon Clardy
Researcher at Harvard University
Publications - 990
Citations - 62414
Jon Clardy is an academic researcher from Harvard University. The author has contributed to research in topics: Absolute configuration & Bacteria. The author has an hindex of 116, co-authored 983 publications receiving 56617 citations. Previous affiliations of Jon Clardy include Howard Hughes Medical Institute & University of Chicago.
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The next opportunity in anti-malaria drug discovery: the liver stage.
TL;DR: Research on the frequency of differentially expressed genes in blood and liver stage parasites supports the feasibility of discovering stage-specific drugs for malaria, and requires a high-throughput liver stage phenotypic screen comparable to the existing blood stage screens.
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Paspalinine, a tremorgenic metabolite from Claviceps paspali Stevens et Hall.
Rex T. Gallagher,Janet S. Finer,Jon Clardy,Albert Leutwiler,Franz R. Weibel,Werner Acklin,Duilio Arigoni +6 more
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Akkermansia muciniphila phospholipid induces homeostatic immune responses
Munhyung Bae,Chelsi D. Cassilly,Xiaoxi Liu,Sung Soo Park,Betsabeh Khoramian Tusi,Xiangjun Chen,Jaeyoung Kwon,Pavel Filipčík,Andrew Bolze,Zehua Liu,Hera Vlamakis,Daniel B. Graham,Sara J. Buhrlage,Ramnik J. Xavier,Jon Clardy +14 more
TL;DR: In this article , a diacyl phosphatidylethanolamine with two branched chains was identified from Akkermansia muciniphila's cell membrane and characterized through both spectroscopic analysis and chemical synthesis.
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Crystal Structure of the N-terminal Segment of Human Eukaryotic Translation Initiation Factor 2α
TL;DR: The first structural analysis of a 22-kDa N-terminal portion of human eIF2α by x-ray diffraction is reported, which contains two major domains and meets along a negatively charged groove with highly conserved residues, indicating a likely site for protein-protein interaction.
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Targeted discovery of polycyclic tetramate macrolactams from an environmental Streptomyces strain.
TL;DR: A targeted polymerase chain reaction (PCR)-based screening approach was used to identify candidate polycyclic tetramate macrolactam (PTM) biosynthetic gene clusters in environmental Streptomyces isolates and confirmed the production of two new PTMs.