J
Jon Clardy
Researcher at Harvard University
Publications - 990
Citations - 62414
Jon Clardy is an academic researcher from Harvard University. The author has contributed to research in topics: Absolute configuration & Bacteria. The author has an hindex of 116, co-authored 983 publications receiving 56617 citations. Previous affiliations of Jon Clardy include Howard Hughes Medical Institute & University of Chicago.
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The structure of gascardic acid from an x-ray diffraction study
TL;DR: The complete structure of the unique tricyclic sesterterpene gascardic acid was proposed in this article based on a single crystal x-ray diffraction analysis of the dicyclohexylammonium salt.
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Synthesis and in vitro DMPK profiling of a 1,2-dioxolane-based library with activity against Plasmodium falciparum
Derek C. Martyn,Galina Beletsky,Joseph F. Cortese,Erin Tyndall,Hanlan Liu,Maria Fitzgerald,Thomas O'Shea,Beirong Liang,Jon Clardy,Jon Clardy +9 more
TL;DR: A 43-member 1,2-dioxolane library was synthesized by coupling a 1, 2-doxolane-3-acetic acid derivative to a range of amines, which revealed that side chains with a heteroatom were required for favorable solubility, LogD and membrane permeability.
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Clavepictines A and B: Cytotoxic Quinolizidines from the Tunicate Clavelina picta
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The Neuroprotective Marine Compound Psammaplysene A Binds the RNA-Binding Protein HNRNPK.
Marco Boccitto,Nayoung Lee,Satoshi Sakamoto,Lynn A. Spruce,Hiroshi Handa,Jon Clardy,Steven H. Seeholzer,Robert G. Kalb,Robert G. Kalb +8 more
TL;DR: Findings suggest a role for HNRNPK-dependent processes in neurodegeneration/neuroprotection, and warrant further study of HNR NPK in this context.