J
Jon Clardy
Researcher at Harvard University
Publications - 990
Citations - 62414
Jon Clardy is an academic researcher from Harvard University. The author has contributed to research in topics: Absolute configuration & Bacteria. The author has an hindex of 116, co-authored 983 publications receiving 56617 citations. Previous affiliations of Jon Clardy include Howard Hughes Medical Institute & University of Chicago.
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Marginatafuran. a furanoditerpene with a new carbon skeleton from the dorid nudibranch
TL;DR: The structure of marginatafuran (1), a furanoditerpene isolated from specimens of Cadlina luteomarginata collected in the Queen Charlotte Islands, was solved via X-ray diffraction analysis as discussed by the authors.
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Natural Product Screening Reveals Naphthoquinone Complex I Bypass Factors.
Scott Bradley Vafai,Emily Mevers,Kathleen W. Higgins,Kathleen W. Higgins,Yevgenia Fomina,Yevgenia Fomina,Jianming Zhang,Anna Mandinova,David Newman,Stanley Y. Shaw,Jon Clardy,Vamsi K. Mootha,Vamsi K. Mootha +12 more
TL;DR: Six novel complex I bypass factors reported here expand this class of molecules and will be useful as tool compounds for investigating complex I disease biology.
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Synthesis of spiro-1,2-dioxolanes and their activity against Plasmodium falciparum.
Derek C. Martyn,Armando P. Ramirez,Meaghan J. Beattie,Joseph F. Cortese,Vishal Patel,Vishal Patel,Margaret A. Rush,Margaret A. Rush,K. A. Woerpel,Jon Clardy,Jon Clardy +10 more
TL;DR: This work has investigated spiro-1,2-dioxolanes as an alternative scaffold for malaria chemotherapy by synthesizing eight analogs that gave EC(50) values of 50-150 nM against Plasmodium falciparum 3D7 and Dd2 strains.
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The Crystalline Sponge Method: A Solvent-Based Strategy to Facilitate Noncovalent Ordered Trapping of Solid and Liquid Organic Compounds.
TL;DR: The new target molecule inclusion method using methyl tert-butyl ether (MTBE) solvent was demonstrated by trapping (E)-stilbene, vanillin, 4-(trifluoromethyl)phenyl azide, and (+)-artemisinin (an antimalarial drug), effectively enabling the potential for high-throughput analysis.