J
Jon Clardy
Researcher at Harvard University
Publications - 990
Citations - 62414
Jon Clardy is an academic researcher from Harvard University. The author has contributed to research in topics: Absolute configuration & Bacteria. The author has an hindex of 116, co-authored 983 publications receiving 56617 citations. Previous affiliations of Jon Clardy include Howard Hughes Medical Institute & University of Chicago.
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Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways
Lihua Ye,Munhyung Bae,Chelsi D. Cassilly,Sairam V. Jabba,Daniel W. Thorpe,Alyce M. Martin,Hsiu-Yi Lu,Jinhu Wang,John D. Thompson,Colin R. Lickwar,Kenneth D. Poss,Damien J. Keating,Sven-Eric Jordt,Jon Clardy,Rodger A. Liddle,Rodger A. Liddle,John F. Rawls +16 more
TL;DR: In this article, the authors used real-time measurements of enteroendocrine cells (EECs) and found that the bacteria Edwardsiella tarda activate EECs through the receptor transient receptor potential ankyrin A1 (Trpa1) and increase intestinal motility.
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Catecholate Siderophores Protect Bacteria from Pyochelin Toxicity
Conrado Adler,Natalia Soledad Corbalan,Mohammad R. Seyedsayamdost,Maria Fernanda Pomares,Ricardo Ezequiel de Cristobal,Jon Clardy,Roberto Kolter,Paula Andrea Vincent +7 more
TL;DR: It is shown that the catecholate siderophore enterobactin protects E. coli against the toxic effects of pyochelin by reducing ROS, which supports the idea that sidersophores can have physiological roles aside from those in iron acquisition.
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Structure-activity studies of rapamycin analogs: evidence that the C-7 methoxy group is part of the effector domain and positioned at the FKBP12-FRAP interface
Juan I. Luengo,Dennis S. Yamashita,Damien J. Dunnington,Arda Konialian Beck,Leonard W. Rozamus,Hwa-Kwo Yen,Mary J. Bossard,Mark Alan Levy,Annalisa Hand,Tonie Newman-Tarr,Alison Badger,Leo F. Faucette,Randall K. Johnson,Karla D'Alessio,Terence Porter,Arthur Shu,Richard Heys,Jungwon Choi,Polongpon Kongsaeree,Jon Clardy,Dennis A. Holt +20 more
TL;DR: It is concluded that the C-7 methoxy group of rapamycin is part of the effector domain in the ternary complex, this group is situated in close proximity to FRAP, at the interface between FRAP and FKBP12.
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Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.
Vishal Patel,Michael Booker,Martin Kramer,Leila S. Ross,Cassandra Celatka,Leah M. Kennedy,Jeffrey D. Dvorin,Jeffrey D. Dvorin,Manoj T. Duraisingh,Piotr Sliz,Dyann F. Wirth,Jon Clardy +11 more
TL;DR: Using a target-based high throughput screen, a series of potent, species-specific inhibitors of P. falciparum DHOD are identified and validated as an antimalarial drug target and provide chemical scaffolds with which to begin medicinal chemistry efforts.
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Structure and biosynthesis of borophycin, a new Boeseken complex of boric acid from a marine strain of the blue-green alga Nostoc linckia
Thomas Hemscheidt,Melany P. Puglisi,Linda K. Larsen,Gregory M. L. Patterson,Richard E. Moore,Jorge L. Rios,Jon Clardy +6 more
TL;DR: The lipophilic extract of a marine strain of Nostoc Zinckia (Roth) Bornet ex Bomet & Flahault (UH isolate GA-5-23) was found to display appreciable cytotoxicity against LoVo and KB, two human tumor cell lines used routinely in the laboratory for screening.