J
Jon Clardy
Researcher at Harvard University
Publications - 990
Citations - 62414
Jon Clardy is an academic researcher from Harvard University. The author has contributed to research in topics: Absolute configuration & Bacteria. The author has an hindex of 116, co-authored 983 publications receiving 56617 citations. Previous affiliations of Jon Clardy include Howard Hughes Medical Institute & University of Chicago.
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Isolation and structure of rebeccamycin - a new antitumor antibiotic from nocardia aerocoligenes
TL;DR: The isolation and structure elucidation of rebeccamycin 1, a new antitumor agent from , is described and the NMR spectra of 1 and its peracetate 2 are discussed.
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Torreyanic Acid: A Selectively Cytotoxic Quinone Dimer from the Endophytic Fungus Pestalotiopsis microspora
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High-Throughput Plasmodium falciparum Growth Assay for Malaria Drug Discovery
TL;DR: A P. falciparum growth assay is reported that is technically simple, robust, and compatible with the automation necessary for HTS, and 181 small molecules were identified as highly active against multidrug-resistant parasites.
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Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
Kimberly J. Briggs,Peppi Koivunen,Shugeng Cao,Keriann M. Backus,Benjamin A. Olenchock,Hetalben Patel,Qing Zhang,Sabina Signoretti,Gary J. Gerfen,Andrea L L. Richardson,Agnieszka K. Witkiewicz,Benjamin F. Cravatt,Jon Clardy,William G. Kaelin,William G. Kaelin +14 more
TL;DR: It is confirmed that TNBC cells secrete glutamate, which is found to be both necessary and sufficient for the paracrine induction of HIF1α in such cells under normoxic conditions.
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Biosynthesis of the Caenorhabditis elegans dauer pheromone
TL;DR: It is shown that daf-22 encodes a homolog of human sterol carrier protein SCPx, which catalyzes the final step in peroxisomal fatty acid β-oxidation, which is required for dauer pheromone production to metabolic state.