J
Jon Clardy
Researcher at Harvard University
Publications - 990
Citations - 62414
Jon Clardy is an academic researcher from Harvard University. The author has contributed to research in topics: Absolute configuration & Bacteria. The author has an hindex of 116, co-authored 983 publications receiving 56617 citations. Previous affiliations of Jon Clardy include Howard Hughes Medical Institute & University of Chicago.
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Selvamicin, an atypical antifungal polyene from two alternative genomic contexts
Ethan B. Van Arnam,Antonio C. Ruzzini,Clarissa S. Sit,Heidi A. Horn,Adrián A. Pinto-Tomás,Cameron R. Currie,Jon Clardy +6 more
TL;DR: The discovery of selvamicin, an unusual antifungal polyene macrolide, in bacterial isolates from two neighboring ant nests is discovered, illustrating the biosynthetic gene cluster mobility that underlies the diversity and distribution of chemical defenses by the specialized bacteria in this multilateral symbiosis.
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An indole-containing dauer pheromone component with unusual dauer inhibitory activity at higher concentrations.
TL;DR: Using activity-guided fractionation and NMR-based structure elucidation, a structurally novel, indole-3-carboxyl-modified ascaroside is identified that promotes dauer formation at low nanomolar concentrations but inhibits dauer Formation at higher concentrations.
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CR377, a new pentaketide antifungal agent isolated from an endophytic fungus.
Sean F. Brady,Jon Clardy +1 more
TL;DR: CR377, a new pentaketide antifungal agent, was isolated from the culture broth of a fungus, CR377 (Fusarium sp.), that showed potent activity against Candida albicans in this assay.
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Psychrotrophic strain of Janthinobacterium lividum from a cold Alaskan soil produces prodigiosin.
Patrick D. Schloss,Heather K. Allen,Amy K. Klimowicz,Christine Mlot,Jessica A. Gross,Sarah Savengsuksa,Jennifer McEllin,Jon Clardy,Roger W. Ruess,Jo Handelsman +9 more
TL;DR: The results show that characterization of cultured organisms from previously unexplored environments can expand the current portrait of the microbial world.
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Progestins activate the AKT pathway in leiomyoma cells and promote survival.
Anna V. Hoekstra,Elizabeth C. Sefton,Emily Berry,Zhenxiao Lu,Jennifer L. Hardt,Erica E. Marsh,Ping Yin,Jon Clardy,Debabrata Chakravarti,Serdar E. Bulun,J. Julie Kim +10 more
TL;DR: Inhibitors of the AKT pathway were used to demonstrate the role of phosphatidylinositol 3-kinase, AKT, and FOXO1 in contributing to cell proliferation and apoptosis in leiomyoma cells.