J
Jon Lindstrom
Researcher at University of Pennsylvania
Publications - 442
Citations - 50369
Jon Lindstrom is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Acetylcholine receptor & Nicotinic agonist. The author has an hindex of 108, co-authored 441 publications receiving 48999 citations. Previous affiliations of Jon Lindstrom include University of California, San Diego & University of California, Riverside.
Papers
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Journal ArticleDOI
N-Methyl-D-aspartate receptor mediated toxicity in nonneuronal cell lines: characterization using fluorescent measures of cell viability and reactive oxygen species production.
Norifusa J. Anegawa,Rodney P. Guttmann,Elfrida R. Grant,René Anand,Jon Lindstrom,David A. Lynch +5 more
TL;DR: Using co-transfection with green fluorescent protein and cell counting of viable cells with a fluorescence activated cells sorter, the subunit-specific profile of NMDA receptor-mediated cell death in cells transfected with NMDA receptors was confirmed.
Journal ArticleDOI
Optical studies of nicotinic acetylcholine receptor subtypes in the guinea-pig enteric nervous system.
TL;DR: The range of activity patterns that follows sequential pharmacological elimination of individual subtypes suggests that nAChRs may be capable of regulating the activity of both excitatory and inhibitory pathways, in a manner similar to that described in the central nervous system.
Journal ArticleDOI
Expression of lynx1 in developing lung and its modulation by prenatal nicotine exposure
Harmanjatinder S. Sekhon,Harmanjatinder S. Sekhon,Pingfang Song,Yibing Jia,Jon Lindstrom,Eliot R. Spindel +5 more
TL;DR: Lynx1 expression was first observed in 71-day fetal lungs and increased with age, and immunohistochemistry, Western analysis, and realtime PCR analysis showed increased lynX1 expression in lungs following prenatal nicotine exposure, suggesting lynx1 is co-expressed with nAChR in the lung.
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α-Conotoxin PeIA[S9H,V10A,E14N] Potently and Selectively Blocks α6β2β3 versus α6β4 Nicotinic Acetylcholine Receptors
Arik J. Hone,Mick'l Scadden,Joanna Gajewiak,Sean Christensen,Jon Lindstrom,J. Michael McIntosh +5 more
TL;DR: Novel analogs of a recently described α-conotoxin, PeIA, are synthesized and it is demonstrated that ligands can be developed to discriminate between α6β2 and α6 β4 nAChRs.
Journal ArticleDOI
Isoform-specific mechanisms of α3β4*-nicotinic acetylcholine receptor modulation by the prototoxin lynx1
TL;DR: The exquisite isoform selectivity of lynx1 interactions provides new insights into the mechanisms and allosteric sites [α(−)‐interface containing] by which prototoxins can modulate nAChR function.