J
Jon Lindstrom
Researcher at University of Pennsylvania
Publications - 442
Citations - 50369
Jon Lindstrom is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Acetylcholine receptor & Nicotinic agonist. The author has an hindex of 108, co-authored 441 publications receiving 48999 citations. Previous affiliations of Jon Lindstrom include University of California, San Diego & University of California, Riverside.
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Journal ArticleDOI
Physical activity modifies the effect of SNPs in the SLC2A2 (GLUT2) and ABCC8 (SUR1) genes on the risk of developing type 2 diabetes
Tuomas O. Kilpeläinen,Timo A. Lakka,David E. Laaksonen,Olli Laukkanen,Jon Lindstrom,Johan G. Eriksson,Valle Tt,Helena Hämäläinen,S. Aunola,Pirjo Ilanne-Parikka,Sirkka Keinänen-Kiukaanniemi,Jaakko Tuomilehto,M. I. J. Uusitupa,Markku Laakso +13 more
TL;DR: Single nucleotide polymorphisms in two genes regulating insulin secretion, SLC2A2 and ABCC8, were associated with the conversion from impaired glucose toleration to impaired glucose tolerance in mice with type 2 diabetes.
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Is “seronegative” MG explained by autoantibodies to MuSK?
TL;DR: The observations support the growing evidence that the prevalence of MuSK antibodies is increasing, and support the view that muscle-specific receptor tyrosine kinase antibodies are important in seronegative myasthenia gravis patients.
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Discovery of peptide ligands through docking and virtual screening at nicotinic acetylcholine receptor homology models
Abba E. Leffler,Alexander Kuryatov,Henry Zebroski,Susan R. Powell,Petr Filipenko,Petr Filipenko,Petr Filipenko,Adel K. Hussein,Adel K. Hussein,Juliette Gorson,Anna Heizmann,Sergey Lyskov,Richard W. Tsien,Sébastien F. Poget,Sébastien F. Poget,Annette Nicke,Jon Lindstrom,Bernardo Rudy,Richard Bonneau,Mandë Holford +19 more
TL;DR: A docking algorithm, ToxDock, which used ensemble-docking and extensive conformational sampling to dock α-GID and its analogs to an α4β2 nAChR homology model, and is extendable to other toxin peptides and ion channels.
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Improved fibrinolysis by an intensive lifestyle intervention in subjects with impaired glucose tolerance. The Finnish Diabetes Prevention Study.
Helena Hämäläinen,Tapani Rönnemaa,Arja Virtanen,Jon Lindstrom,Johan G. Eriksson,Valle Tt,Pirjo Ilanne-Parikka,Sirkka Keinänen-Kiukaanniemi,Rastas M,S. Aunola,M. I. J. Uusitupa,J. Tuomilehto +11 more
TL;DR: The results suggest that elevated PAI-1 levels in obese subjects with impaired glucose tolerance are mostly reversible by lifestyle changes, especially those geared to weight reduction.
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In vitro inhibition of adrenal catecholamine secretion by steroidal metabolites of ginseng saponins.
Eiichi Tachikawa,Kenzo Kudo,Hideo Hasegawa,Takeshi Kashimoto,Kazuhiko Sasaki,Masao Miyazaki,Hideharu Taira,Jon Lindstrom +7 more
TL;DR: The results suggest that the major ginsenoside metabolites act on nicotinic ACh receptors, blocking Na(+) influx through the receptors, and consequently reduce the catecholamine secretion from bovine adrenal chromaffin cells.