J
Jon Lindstrom
Researcher at University of Pennsylvania
Publications - 442
Citations - 50369
Jon Lindstrom is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Acetylcholine receptor & Nicotinic agonist. The author has an hindex of 108, co-authored 441 publications receiving 48999 citations. Previous affiliations of Jon Lindstrom include University of California, San Diego & University of California, Riverside.
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Passive transfer of experimental autoimmune myasthenia gravis by monoclonal antibodies to the main immunogenic region of the acetylcholine receptor
TL;DR: All four mAbs directed at the MIR of the nicotinic acetylcholine receptor were very efficient in inducing EAMG: within 2 days the rats became moribund or very weak and their muscle AChR content decreased to about 50% of normal.
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Single-channel recordings from purified acetylcholine receptors reconstituted in bilayers formed at the tip of patch pipets
TL;DR: The results suggest that the full cycle of solubilization, purification, and reconstitution of this membrane receptor can be achieved without impairment of channel function.
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Expression of nicotinic acetylcholine receptor subunits in the cerebral cortex in Alzheimer's disease: histotopographical correlation with amyloid plaques and hyperphosphorylated-tau protein.
Andrea Wevers,Lisa M. Monteggia,Sonja Nowacki,Wilhelm Bloch,Ulrich Schütz,Jon Lindstrom,Edna F. R. Pereira,Howard M. Eisenberg,Ezio Giacobini,R. A. I. de Vos,E.N.H. Jansen Steur,Alfred Maelicke,Edson X. Albuquerque,Edson X. Albuquerque,Hannsjörg Schröder +14 more
TL;DR: The results point to an impaired synthesis of nAChRs on the protein level as a possible cause of the cholinoceptive deficit in AD.
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Human alpha4beta2 acetylcholine receptors formed from linked subunits.
TL;DR: Preparing concatamers of α4 and β2 subunits for human nicotinic acetylcholine receptors (AChRs) and expressing them in Xenopus oocytes provide insight into the structure and function of α 4β2 AChRs, emphasizing the functional differences between α4 β2 A ChRs of different stoichiometries.
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Nicotinic Acetylcholine Receptors of Muscles and Nerves
TL;DR: There are fetal and adult subtypes of muscle nicotinic receptors (AChRs), whose structures and functional roles are reasonably well known, which have thus far been associated with rare forms of epilepsy and dysautonomia, but other genetic diseases associated with them probably remain to be discovered.