J
Jon Lindstrom
Researcher at University of Pennsylvania
Publications - 442
Citations - 50369
Jon Lindstrom is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Acetylcholine receptor & Nicotinic agonist. The author has an hindex of 108, co-authored 441 publications receiving 48999 citations. Previous affiliations of Jon Lindstrom include University of California, San Diego & University of California, Riverside.
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Journal ArticleDOI
Nicotinic receptors in non-human primates: Analysis of genetic and functional conservation with humans.
Lyndsey E. Shorey-Kendrick,Matthew M. Ford,Daicia C. Allen,Alexander Kuryatov,Jon Lindstrom,Larry J. Wilhelm,Kathleen A. Grant,Eliot R. Spindel +7 more
TL;DR: The combination of highly homologous nAChR, higher cortical functions and capacity for complex training makes non-human primates a unique model to study in vivo functions of nicotinic receptors and studies on nicotine addiction are likely to be highly predictive of treatment outcomes in humans.
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The genetic variation in the tenomodulin gene is associated with serum total and LDL cholesterol in a body size-dependent manner.
Tolppanen Am,Leena Pulkkinen,Tiina Kuulasmaa,Marjukka Kolehmainen,Ursula Schwab,Jon Lindstrom,Jaakko Tuomilehto,M. I. J. Uusitupa,Johanna Kuusisto +8 more
TL;DR: In this paper, the authors reported that the sequence variation in the tenomodulin (TNMD) gene is associated with the risk of type 2 diabetes, central obesity and serum levels of systemic immune mediators in the Finnish Diabetes Prevention Study (DPS), which is a longitudinal lifestyle intervention study on 522 middle-aged persons with impaired glucose tolerance (IGT).
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Cellular prion protein co‐localizes with nAChR β4 subunit in brain and gastrointestinal tract
Spyros Petrakis,T. Irinopoulou,Cynthia H. Panagiotidis,Roni Engelstein,Jon Lindstrom,Avi Orr-Urtreger,R. Gabizon,N. Grigoriadis,Theodoros Sklaviadis +8 more
TL;DR: The results suggest that PrPC is a member of a multiprotein membrane complex participating in the formation and function of α3β4 nAChR, as indicated by co‐immunoprecipitation assays and double‐label immunofluorescence.
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Immunopathology of acetylcholine receptors in myasthenia gravis.
TL;DR: Treatment for MG continues to rely heavily on the symptomatic relief afforded by acetylcholinesterase inhibitors, but the recent recognition of the autoimmune nature of MG has led to increased emphasis on immunosuppression and antibody removal with some beneficial effects.
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Purification of acetylcholine receptors from the muscle of Electrophorus electricus.
TL;DR: Receptor was purified from Electrophorus muscle by affinity chromatography on cobra toxin-agarose and found to contain subunits which correspond immunochemically to the alpha, beta, gamma, and delta subunits of receptor from electric organ tissue of Torpedo californica.