J
Jon Lindstrom
Researcher at University of Pennsylvania
Publications - 442
Citations - 50369
Jon Lindstrom is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Acetylcholine receptor & Nicotinic agonist. The author has an hindex of 108, co-authored 441 publications receiving 48999 citations. Previous affiliations of Jon Lindstrom include University of California, San Diego & University of California, Riverside.
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Book ChapterDOI
Structural and functional heterogeneity of nicotinic receptors.
TL;DR: Achlioptas et al. as mentioned in this paper used monoclonal antibodies and cDNA probes to characterize neuronal AChR subtypes and found that they are members of the ligand-gated ion channel gene family.
Journal ArticleDOI
Localized low-level re-expression of high-affinity mesolimbic nicotinic acetylcholine receptors restores nicotine-induced locomotion but not place conditioning.
Yann S. Mineur,Darlene H. Brunzell,Darlene H. Brunzell,Sharon R. Grady,Jon Lindstrom,J.M. McIntosh,Michael J. Marks,Sarah L. King,Sarah L. King,Marina R. Picciotto +9 more
TL;DR: Responses in mice with low‐level VTA expression suggest that partial activation of high‐affinity nAChRs in VTA might block the rewarding effects of nicotine, providing a potential mechanism for the ability of nicotinic partial agonists to aid in smoking cessation.
Journal ArticleDOI
Autoimmune diseases involving nicotinic receptors.
TL;DR: The antibody-mediated autoimmune response to alpha1 muscle nicotinic acetylcholine receptors that causes myasthenia gravis is one of the best characterized autoimmune diseases.
Journal ArticleDOI
Characterization of the mRNA for mouse muscle acetylcholine receptor alpha subunit by quantitative translation in vitro.
TL;DR: It is shown that in BC3H-1 cells, alpha subunit mRNA is regulated developmentally and a 10-fold increase in the relative abundance of alpha sub unit mRNA was detected in cells which had undergone the transition from log phase growth to differentiated myoblast.
Journal ArticleDOI
Myasthenia Gravis and the Tops and Bottoms of AChRs Antigenic Structure of the MIR and Specific Immunosuppression of EAMG Using AChR Cytoplasmic Domains
TL;DR: The main immunogenic region (MIR) of myasthenia gravis (MG) or experimental autoimmune MG (EAMG) is located at the extracellular end of α1 subunits, and the presence of the MIR epitopes in α1/α7 chimeras greatly promotes AChR expression and sensitivity to activation.