J
Jon Lindstrom
Researcher at University of Pennsylvania
Publications - 442
Citations - 50369
Jon Lindstrom is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Acetylcholine receptor & Nicotinic agonist. The author has an hindex of 108, co-authored 441 publications receiving 48999 citations. Previous affiliations of Jon Lindstrom include University of California, San Diego & University of California, Riverside.
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Book ChapterDOI
The Molecular Basis of Neurotransmission: Structure and Function of the Nicotinic Acetylcholine Receptor
TL;DR: Acetylcholine receptors at the neuromuscular junctions of striated muscle and at the synapses of fish electric organs (which are phylogenetically related to muscle tissue) are the best-studied nicotinic acetylCholine receptors and the subjects of this review.
Journal ArticleDOI
GABA-like immunoreactive cells containing nicotinic acetylcholine receptors in the chick retina
D. E. Hamassaki-Britto,Agnieszka Brzozowska-Prechtl,Harvey J. Karten,Jon Lindstrom,Kent T. Keyser +4 more
TL;DR: The present data appear to represent the first demonstration of the presence of acetylcholine receptors in GABA‐containing cells in the retina, thus providing a basis for a possible influence of acetolcholine upon those presumptive GABAergic cells.
Journal ArticleDOI
Using monoclonal antibodies to determine the structures of acetylcholine receptors from electric organs, muscles, and neurons.
Jon Lindstrom,Manuel Criado,Manohar Ratnam,Paul J. Whiting,Scott Ralston,Jean Rivier,Virender K. Sarin,Peter B. Sargent +7 more
TL;DR: Using antibodies to study acetylcholine receptors led to the discovery that the muscular weakness characteristic of myasthenia gravis is caused by an autoimmune response to AChRs.
Journal ArticleDOI
Reduced muscle acetylcholine sensitivity in rats immunised with acetylcholine receptor.
TL;DR: There is a factor in the serum of immunised rats which can reduce the ACh sensitivity of denervated rat muscles in vitro, and this factor is found to be antibody to AChR isolated from rat skeletal muscle.
Journal ArticleDOI
Monoclonal antibodies specific to the beta and gamma subunits of the Torpedo acetylcholine receptor inhibit single-channel activity.
TL;DR: Single-channel recordings from the Torpedo californica purified ACh receptor reconstituted in planar lipid bilayers were used as the assay to evaluate the influence of distinct mAbs on the ion conduction and gating characteristics of the A Ch receptor channel.