J
Jon Lindstrom
Researcher at University of Pennsylvania
Publications - 442
Citations - 50369
Jon Lindstrom is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Acetylcholine receptor & Nicotinic agonist. The author has an hindex of 108, co-authored 441 publications receiving 48999 citations. Previous affiliations of Jon Lindstrom include University of California, San Diego & University of California, Riverside.
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Journal ArticleDOI
The effects of inhibiting oligosaccharide trimming by 1-deoxynojirimycin on the nicotinic acetylcholine receptor.
TL;DR: It is concluded that oligosaccharide processing either may aid in protecting the alpha subunit primary translation product from degradation or may be required for the conformational change or other post-translational modification(s) necessary for formation of the alpha-bungarotoxin binding form of thealpha subunit, which is then protected from proteolytic degradation.
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Probing nicotinic acetylcholine receptors with monoclonal antibodies
TL;DR: How monoclonal antibodies are used to study the synthesis, structure, function and autoimmune response to AChRs in mammalian skeletal muscle and fish electric organs and how they have been used to identify A ChRs in neurons are reviewed.
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Alcohol modulation of neuronal nicotinic acetylcholine receptors is alpha subunit dependent.
TL;DR: The alpha3beta2 AChRs are insensitive to ethanol because ethanol is at the transition point from potentiation to inhibition among n-alcohols with different carbon-chain lengths, which explains the differential action of ethanol on the central nervous system.
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Parvalbumin-containing interneurons of the human cerebral cortex express nicotinic acetylcholine receptor proteins.
Ingmar Krenz,Dilek Kalkan,Andrea Wevers,Rob A.I. de Vos,Ernst N.H. Jansen Steur,Jon Lindstrom,Kirsten Pilz,Sonja Nowacki,Ulrich Schütz,Natasha Moser,Brigitte Witter,Hannsjörg Schröder +11 more
TL;DR: This work applied double-immunofluorescence using antibodies against parvalbumin --a marker for the Chandelier and basket cell subpopulation of interneurons--and to the alpha4 and alpha7 subunit proteins of the nicotinic acetylcholine receptor to show the connectivity pattern of cholinergic afferents appears much more complex than thought before.
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Standardization of the experimental autoimmune myasthenia gravis (EAMG) model by immunization of rats with Torpedo californica acetylcholine receptors--Recommendations for methods and experimental designs.
Mario Losen,Pilar Martinez-Martinez,Peter C. M. Molenaar,Konstantinos Lazaridis,Socrates J. Tzartos,Talma Brenner,Rui-Sheng Duan,Jie Luo,Jon Lindstrom,Linda L. Kusner +9 more
TL;DR: Standard operation procedures and recommendations are defined for the rat EAMG model using purified AChR from the Torpedo californica electric organ in order to facilitate more rapid translation of preclinical proof of concept or efficacy studies into clinical trials and, ultimately, clinical practice.