L
Lennart Opitz
Researcher at University of Zurich
Publications - 92
Citations - 4487
Lennart Opitz is an academic researcher from University of Zurich. The author has contributed to research in topics: Transcriptome & Stem cell. The author has an hindex of 31, co-authored 84 publications receiving 3490 citations. Previous affiliations of Lennart Opitz include University of Göttingen & École Polytechnique Fédérale de Lausanne.
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Journal ArticleDOI
Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice
Shahaf Peleg,Farahnaz Sananbenesi,Athanasios Zovoilis,Susanne Burkhardt,Sanaz Bahari-Javan,Roberto Carlos Agis-Balboa,Perla Cota,Jessica Wittnam,Andreas Gogol-Doering,Lennart Opitz,Gabriella Salinas-Riester,Markus Dettenhofer,Hui Kang,Laurent Farinelli,Wei Chen,Andre Fischer +15 more
TL;DR: It is shown that memory disturbances in the aging brain of the mouse are associated with altered hippocampal chromatin plasticity, and data suggest that deregulated H4K12 acetylation may represent an early biomarker of an impaired genome-environment interaction in the Aging mouse brain.
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Memory B Cells Activate Brain-Homing, Autoreactive CD4+ T Cells in Multiple Sclerosis.
Ivan Jelcic,Faiez Al Nimer,Faiez Al Nimer,Jian Wang,Verena Lentsch,Raquel Planas,Ilijas Jelcic,Aleksandar Madjovski,Sabrina Ruhrmann,Wolfgang Faigle,Katrin Frauenknecht,Clemencia Pinilla,Radleigh G. Santos,Christian Hammer,Christian Hammer,Yanneth Ortiz,Lennart Opitz,Hans Grönlund,Gerhard Rogler,Onur Boyman,Richard Reynolds,Andreas Lutterotti,Mohsen Khademi,Tomas Olsson,Frederik Piehl,Mireia Sospedra,Roland Martin +26 more
TL;DR: It is demonstrated that self-reactivity, defined as “autoproliferation” of peripheral Th1 cells, is elevated in patients carrying the HLA-DR15 haplotype, and RASGRP2 is identified as target autoantigen that is expressed in the brain and B cells.
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Impact of RNA degradation on gene expression profiling
Lennart Opitz,Gabriela Salinas-Riester,Marian Grade,Klaus Jung,Peter Jo,Georg Emons,B. Michael Ghadimi,Tim Beißbarth,Jochen Gaedcke +8 more
TL;DR: Degraded RNA from tumor samples (RIN > 5) can still be used to perform gene expression analysis, but there are genes, very short ones and those with the probe binding side close to the 5' end that should be excluded from gene expressionAnalysis when working with degraded RNA.
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The forebrain synaptic transcriptome is organized by clocks but its proteome is driven by sleep.
Sara B. Noya,David Colameo,Franziska Brüning,Franziska Brüning,Andrea Spinnler,Dennis Mircsof,Lennart Opitz,Matthias Mann,Matthias Mann,Shiva K. Tyagarajan,Maria S. Robles,Steven A. Brown +11 more
TL;DR: Examining the dynamics of mRNAs in the synaptic landscape revealed the largest proportion of circadian transcripts in any tissue, cell, or organelle described to date, and comprehensive circadian characterization of the synaptic proteome demonstrated the functional relevance of this temporal gating for synaptic function and energy homeostasis.
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A hippocampal insulin-growth factor 2 pathway regulates the extinction of fear memories.
Roberto Carlos Agis-Balboa,Dario Arcos-Diaz,Jessica Wittnam,Nambirajan Govindarajan,Kim Blom,Susanne Burkhardt,Ulla Haladyniak,Hope Y Agbemenyah,Athanasios Zovoilis,Gabriella Salinas-Riester,Lennart Opitz,Farahnaz Sananbenesi,Andre Fischer,Andre Fischer +13 more
TL;DR: It is demonstrated that therapeutic strategies that enhance IGF2 signalling and adult neurogenesis might be suitable to treat disease linked to excessive fear memory, and that fear extinction‐induced IGF2/IGFBP7 signalling promotes the survival of 17–19‐day‐old newborn hippocampal neurons.