Lennart Opitz

TL;DR: It is shown that memory disturbances in the aging brain of the mouse are associated with altered hippocampal chromatin plasticity, and data suggest that deregulated H4K12 acetylation may represent an early biomarker of an impaired genome-environment interaction in the Aging mouse brain.

TL;DR: It is demonstrated that self-reactivity, defined as “autoproliferation” of peripheral Th1 cells, is elevated in patients carrying the HLA-DR15 haplotype, and RASGRP2 is identified as target autoantigen that is expressed in the brain and B cells.

TL;DR: Degraded RNA from tumor samples (RIN > 5) can still be used to perform gene expression analysis, but there are genes, very short ones and those with the probe binding side close to the 5' end that should be excluded from gene expressionAnalysis when working with degraded RNA.

TL;DR: Examining the dynamics of mRNAs in the synaptic landscape revealed the largest proportion of circadian transcripts in any tissue, cell, or organelle described to date, and comprehensive circadian characterization of the synaptic proteome demonstrated the functional relevance of this temporal gating for synaptic function and energy homeostasis.

TL;DR: It is demonstrated that therapeutic strategies that enhance IGF2 signalling and adult neurogenesis might be suitable to treat disease linked to excessive fear memory, and that fear extinction‐induced IGF2/IGFBP7 signalling promotes the survival of 17–19‐day‐old newborn hippocampal neurons.