L
Lin Mei
Researcher at Case Western Reserve University
Publications - 266
Citations - 18002
Lin Mei is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Neuromuscular junction & Agrin. The author has an hindex of 69, co-authored 245 publications receiving 15903 citations. Previous affiliations of Lin Mei include University of Arizona & Chinese Academy of Sciences.
Papers
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Journal ArticleDOI
Neuregulin 1 in neural development, synaptic plasticity and schizophrenia
Lin Mei,Wen Cheng Xiong +1 more
TL;DR: An improved understanding of the mechanisms by which altered function of NRG1 and ErbB4 contributes to schizophrenia might eventually lead to the development of more effective therapeutics.
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Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway.
Kit Wong,Xiu Rong Ren,Yang Zhong Huang,Yi Xie,Guofa Liu,Harumi Saito,Hao Tang,Leng Wen,Susann M. Brady-Kalnay,Lin Mei,Jane Y. Wu,Wen Cheng Xiong,Yi Rao +12 more
TL;DR: It is reported here that the intracellular domain of Robo interacts with a novel family of Rho GTPase activating proteins (GAPs) that are expressed in regions responsive to Slit and demonstrated important roles for GAPs and Cdc42 in neuronal migration.
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To build a synapse: Signaling pathways in neuromuscular junction assembly
TL;DR: This review highlights recent advances in the study of NMJ development, focusing on signaling pathways that are activated by diffusible cues, which shed light on synaptogenesis in the brain and contribute to a better understanding of muscular dystrophy.
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LRP4 serves as a coreceptor of agrin.
TL;DR: Observations indicate that LRP4 is a coreceptor of agrin that is necessary for MuSK signaling and AChR clustering and identify a potential target protein whose mutation and/or autoimmunization may cause muscular dystrophies.
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Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure
Natasha S. Hamblet,Nardos Lijam,Pilar Ruiz-Lozano,Jianbo Wang,Yasheng Yang,Zhenge Luo,Lin Mei,Kenneth R. Chien,Daniel J. Sussman,Anthony Wynshaw-Boris,Anthony Wynshaw-Boris +10 more
TL;DR: Dvl2 is essential for normal cardiac morphogenesis, somite segmentation and neural tube closure, and there is functional redundancy between Dvl1 and Dvl2 in some phenotypes.