L
Lorenzo Bonaguro
Researcher at University of Bonn
Publications - 26
Citations - 2439
Lorenzo Bonaguro is an academic researcher from University of Bonn. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 8, co-authored 17 publications receiving 842 citations. Previous affiliations of Lorenzo Bonaguro include German Center for Neurodegenerative Diseases.
Papers
More filters
Journal ArticleDOI
Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment.
Jonas Schulte-Schrepping,Nico Reusch,Daniela Paclik,Kevin Baßler,Stephan Schlickeiser,Bowen Zhang,Benjamin Krämer,Tobias Krammer,Sophia Brumhard,Lorenzo Bonaguro,Elena De Domenico,Daniel Wendisch,Martin Grasshoff,Theodore S. Kapellos,Michael Beckstette,Tal Pecht,Adem Saglam,Oliver Dietrich,Henrik E. Mei,Axel Schulz,Claudia Conrad,Désirée Kunkel,Ehsan Vafadarnejad,Cheng-Jian Xu,Cheng-Jian Xu,Arik Horne,Miriam Herbert,Anna Drews,Charlotte Thibeault,Moritz Pfeiffer,Stefan Hippenstiel,Andreas C. Hocke,Holger Müller-Redetzky,Katrin-Moira Heim,Felix Machleidt,Alexander Uhrig,Laure Bosquillon de Jarcy,Linda Jürgens,Miriam Stegemann,Christoph R. Glösenkamp,Hans-Dieter Volk,Christine Goffinet,Markus Landthaler,Emanuel Wyler,Philipp Georg,Maria Schneider,Chantip Dang-Heine,Nick Neuwinger,Kai Kappert,Rudolf Tauber,Victor M. Corman,Jan Raabe,Kim Melanie Kaiser,Michael To Vinh,Gereon Rieke,Christian Meisel,Thomas Ulas,Matthias Becker,Robert Geffers,Martin Witzenrath,Christian Drosten,Norbert Suttorp,Christof von Kalle,Florian Kurth,Florian Kurth,Florian Kurth,Kristian Händler,Joachim L. Schultze,Joachim L. Schultze,Anna C. Aschenbrenner,Anna C. Aschenbrenner,Yang Li,Yang Li,Jacob Nattermann,Birgit Sawitzki,Antoine-Emmanuel Saliba,Leif E. Sander,Angel Angelov,Robert Bals,Alexander Bartholomäus,Anke Becker,Daniela Bezdan,Ezio Bonifacio,Peer Bork,Thomas Clavel,Maria Colomé-Tatché,Andreas Diefenbach,Alexander T. Dilthey,Nicole Fischer,Konrad U. Förstner,Julia-Stefanie Frick,Julien Gagneur,Alexander Goesmann,Torsten Hain,Michael Hummel,Stefan Janssen,Jörn Kalinowski,René Kallies,Birte Kehr,Andreas Keller,Sarah Kim-Hellmuth,Christoph Klein,Oliver Kohlbacher,Jan O. Korbel,Ingo Kurth,Kerstin U. Ludwig,Oliwia Makarewicz,Manja Marz,Alice C. McHardy,Christian Mertes,Markus M. Nöthen,Peter Nürnberg,Uwe Ohler,Stephan Ossowski,Jörg Overmann,Silke Peter,Klaus Pfeffer,Anna R. Poetsch,Alfred Pühler,Nikolaus Rajewsky,Markus Ralser,Olaf Rieß,Stephan Ripke,Ulisses Nunes da Rocha,Philip Rosenstiel,Philipp H. Schiffer,Eva-Christina Schulte,Alexander Sczyrba,Oliver Stegle,Jens Stoye,Fabian J. Theis,Janne Vehreschild,Jörg Vogel,Max von Kleist,Andreas Walker,Jörn Walter,Dagmar Wieczorek,John Ziebuhr +137 more
TL;DR: This study provides detailed insights into the systemic immune response to SARS-CoV-2 infection and it reveals profound alterations in the myeloid cell compartment associated with severe COVID-19.
Journal ArticleDOI
Human Monocyte Subsets and Phenotypes in Major Chronic Inflammatory Diseases
Theodore S. Kapellos,Lorenzo Bonaguro,Ioanna Gemünd,Nico Reusch,Adem Saglam,Emily R. Hinkley,Joachim L. Schultze +6 more
TL;DR: An insight is provided into the contribution of human monocytes to the progression of these diseases and their candidacy as potential therapeutic cell targets are highlighted.
Journal ArticleDOI
Swarm Learning for decentralized and confidential clinical machine learning.
Stefanie Warnat-Herresthal,Hartmut Schultze,K. Shastry,Sathyanarayanan Manamohan,Saikat Mukherjee,Vishesh Garg,Ravi Sarveswara,Kristian Händler,Peter Pickkers,N. Ahmad Aziz,Sofia Ktena,Florian Tran,Michael Bitzer,Stephan Ossowski,Nicolas Casadei,Christian Herr,Daniel Petersheim,Uta Behrends,Fabian Kern,Tobias Fehlmann,Philipp Schommers,Clara Lehmann,Max Augustin,Jan Rybniker,Janine Altmüller,Neha Mishra,Joana P. Bernardes,Benjamin Krämer,Lorenzo Bonaguro,Jonas Schulte-Schrepping,Elena De Domenico,Christian Siever,Michael Kraut,Milind Desai,Bruno Monnet,Maria Saridaki,Charles Siegel,Anna Drews,Melanie Nuesch-Germano,Heidi Theis,Jan Heyckendorf,Stefan Schreiber,Sarah Kim-Hellmuth,Jacob Nattermann,Dirk Skowasch,Ingo Kurth,Andreas Keller,Andreas Keller,Robert Bals,Peter Nürnberg,Olaf Rieß +50 more
TL;DR: Wang et al. as mentioned in this paper proposed Swarm Learning, a decentralized machine learning approach that unifies edge computing, blockchain-based peer-to-peer networking and coordination while maintaining confidentiality without the need for a central coordinator.
Journal ArticleDOI
Neutrophils in COVID-19.
Nico Reusch,Nico Reusch,Elena De Domenico,Lorenzo Bonaguro,Lorenzo Bonaguro,Jonas Schulte-Schrepping,Jonas Schulte-Schrepping,Kevin Baßler,Kevin Baßler,Joachim L. Schultze,Joachim L. Schultze,Anna C. Aschenbrenner +11 more
TL;DR: In this article, the authors highlight the observed immune deviation of neutrophils in COVID-19 and summarize several promising therapeutic attempts to precisely target neutrophILS and their reactivity in patients with COVID19.
Journal ArticleDOI
Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients.
Anna C. Aschenbrenner,Maria Mouktaroudi,Benjamin Krämer,Marie Oestreich,Nikolaos Antonakos,Melanie Nuesch-Germano,Konstantina Gkizeli,Lorenzo Bonaguro,Nico Reusch,Kevin Baßler,Maria Saridaki,Rainer Knoll,Tal Pecht,Theodore S. Kapellos,Sarandia Doulou,Charlotte Kröger,Miriam Herbert,Lisa Holsten,Arik Horne,Ioanna D. Gemünd,Nikoletta Rovina,Shobhit Agrawal,Kilian Dahm,Martina van Uelft,Anna Drews,Lena Lenkeit,Niklas Bruse,Jelle Gerretsen,Jannik Gierlich,Matthias Becker,Kristian Händler,Michael Kraut,Heidi Theis,Simachew Mengiste,Elena De Domenico,Jonas Schulte-Schrepping,Lea Seep,Jan Raabe,Christoph Hoffmeister,Michael ToVinh,Verena Keitel,Gereon Rieke,Valentina Talevi,Dirk Skowasch,N. Ahmad Aziz,N. Ahmad Aziz,Peter Pickkers,Frank L. van de Veerdonk,Mihai G. Netea,Mihai G. Netea,Joachim L. Schultze,Joachim L. Schultze,Matthijs Kox,Monique M.B. Breteler,Monique M.B. Breteler,Jacob Nattermann,Antonia Koutsoukou,Evangelos J. Giamarellos-Bourboulis,Thomas Ulas +58 more
TL;DR: This article performed RNA-seq of whole blood cell transcriptomes and granulocyte preparations from mild and severe COVID-19 patients and analyzed the data using a combination of conventional and data-driven co-expression analysis.