Louise Neilson

TL;DR: The publication presents a novel approach for determining the reliability of in silico predictions alongside experimental data and discusses how to determine the level of confidence in the assessment based on the relevance and reliability of the information.

TL;DR: Applicability of the EpiAirway™ model and exposure system was demonstrated, showing little cytotoxicity from e-cigarette aerosol and different aerosol formulations when compared directly with reference cigarette smoke, over the same exposure time.

TL;DR: Based on the relevance of the mechanisms and effects as well as the strengths and limitations of the experimental systems used to identify them, rules and principles are defined for deriving skin sensitization in silico assessments.

TL;DR: The addition of flavourings to the Neostiks tested did not alter the chemical profile of THP emissions or change in vitro responses relative to the unflavoured Neostik, and levels of measured toxicants were similar in the flavoured and unflavours Neostika emissions.

TL;DR: The current status of in silico tools for the assessment of each KC is summarized and the data gaps that need to be addressed are identified before a comprehensive insilico carcinogenicity protocol can be developed for regulatory use.