Journal ArticleDOI
In silico approaches in carcinogenicity hazard assessment: Current status and future needs
Raymond R. Tice,Arianna Bassan,Alexander Amberg,Lennart T. Anger,Marc A. Beal,Phillip Bellion,Romualdo Benigni,Jeffrey M. Birmingham,Alessandro Brigo,Frank Bringezu,Lidia Ceriani,Ian Crooks,Kevin P. Cross,Rosalie K. Elespuru,David Faulkner,Marie C. Fortin,Paul Fowler,Markus Frericks,Helga Gerets,Gloria D. Jahnke,David R. Jones,Naomi L. Kruhlak,Elena Lo Piparo,Juan Lopez-Belmonte,Amarjit Luniwal,Alice Luu,Federica Madia,Serena Manganelli,Balasubramanian Manickam,Jordi Mestres,Amy L. Mihalchik-Burhans,Louise Neilson,Arun R. Pandiri,Manuela Pavan,Cynthia V. Rider,John P. Rooney,Alejandra Trejo-Martin,Karen H. Watanabe-Sailor,Angela White,David Woolley,Glenn J. Myatt +40 more
Reads0
Chats0
TLDR
The current status of in silico tools for the assessment of each KC is summarized and the data gaps that need to be addressed are identified before a comprehensive insilico carcinogenicity protocol can be developed for regulatory use.About:
This article is published in Computational Toxicology.The article was published on 2021-11-01. It has received 16 citations till now.read more
Citations
More filters
A brief history of the DNA repair field
TL;DR: The history of the repair of damaged DNA can be traced to the mid-1930s, when multiple DNA repair mechanisms, as well as other biological responses to DNA damage, have been discovered and their regulation has been studied.
Journal ArticleDOI
In silico approaches in organ toxicity hazard assessment: Current status and future needs in predicting liver toxicity
Arianna Bassan,Vinicius M. Alves,Alexander Amberg,Lennart T. Anger,Scott S. Auerbach,Lisa Beilke,Andreas Bender,Andreas Bender,Mark T. D. Cronin,Kevin P. Cross,Jui-Hua Hsieh,Nigel Greene,Raymond Kemper,Marlene T. Kim,Moiz Mumtaz,Tobias Noeske,Manuela Pavan,Julia Pletz,Daniel P. Russo,Yogesh Sabnis,Markus Schaefer,David T. Szabo,Jean-Pierre Valentin,Joerg Wichard,Dominic P. Williams,David Woolley,Craig Zwickl,Glenn J. Myatt +27 more
TL;DR: The paper describes the increasingly important role of insilico approaches and highlights challenges to the adoption of these methods including the lack of a commonly agreed upon protocol for performing such an assessment and the need for in silico solutions that take dose into consideration.
Journal ArticleDOI
Current status and future directions for a neurotoxicity hazard assessment framework that integrates in silico approaches.
Kevin M. Crofton,Arianna Bassan,Mamta Behl,Yaroslav Chushak,Ellen Fritsche,J.M. Gearhart,M. Sue Marty,Moiz Mumtaz,Manuela Pavan,Patricia Ruiz,Magdalini Sachana,Rajamani Selvam,Timothy J. Shafer,Lidiya Stavitskaya,David T. Szabo,Steven T. Szabo,Raymond R. Tice,Daniel M. Wilson,David E. Woolley,Glenn J. Myatt +19 more
TL;DR: In this paper , a conceptual framework for the integration of in-silico methods with experimental information is presented, which is essential for the development of protocols, namely standardized approaches, to ensure that assessments of NT and DNT based on chemical structures are generated in a transparent, consistent, and defendable manner.
Journal ArticleDOI
A machine learning-driven approach for prioritizing food contact chemicals of carcinogenic concern based on complementary in silico methods
Chun Wei Tung,Pinpin Lin +1 more
TL;DR: In this article , a machine learning-based weight-of-evidence (WoE) model was proposed for prioritizing chemical carcinogenesis, which can nonlinearly integrate complementary computational methods of structural alerts, quantitative structure-activity relationship models and in silico toxicogenomics models into a WoE-score.
Journal ArticleDOI
Rethinking agrochemical safety assessment: A perspective.
TL;DR: In this article, the authors review current initiatives and emerging opportunities to improve agrochemical safety assessment for humans, and consider various endpoints and initiatives (including acute toxicity, repeat dose toxicity studies, carcinogenicity, developmental and reproductive toxicity, exposure-driven approaches, inhalation toxicity, and data modelling).
References
More filters
Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
Journal ArticleDOI
Cancer-related inflammation.
TL;DR: The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.
Journal ArticleDOI
Origin and Physiological Roles of Inflammation
TL;DR: This work has shown that tissue stress or malfunction induces an adaptive response that is intermediate between the basal homeostatic state and a classic inflammatory response, which is referred to here as para-inflammation.
Journal ArticleDOI
Cancer immunoediting: from immunosurveillance to tumor escape.
TL;DR: The historical and experimental basis of cancer immunoediting is summarized and its dual roles in promoting host protection against cancer and facilitating tumor escape from immune destruction are discussed.
Related Papers (5)
In silico approaches in organ toxicity hazard assessment: Current status and future needs in predicting liver toxicity
Arianna Bassan,Vinicius M. Alves,Alexander Amberg,Lennart T. Anger,Scott S. Auerbach,Lisa Beilke,Andreas Bender,Andreas Bender,Mark T. D. Cronin,Kevin P. Cross,Jui-Hua Hsieh,Nigel Greene,Raymond Kemper,Marlene T. Kim,Moiz Mumtaz,Tobias Noeske,Manuela Pavan,Julia Pletz,Daniel P. Russo,Yogesh Sabnis,Markus Schaefer,David T. Szabo,Jean-Pierre Valentin,Joerg Wichard,Dominic P. Williams,David Woolley,Craig Zwickl,Glenn J. Myatt +27 more