L
Ludovic Vallier
Researcher at University of Cambridge
Publications - 199
Citations - 17332
Ludovic Vallier is an academic researcher from University of Cambridge. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 55, co-authored 180 publications receiving 14503 citations. Previous affiliations of Ludovic Vallier include Wellcome Trust & Columbia University.
Papers
More filters
Journal ArticleDOI
Derivation of pluripotent epiblast stem cells from mammalian embryos
I. Gabrielle M. Brons,Lucy E. Smithers,Matthew Trotter,Peter J. Rugg-Gunn,Bowen Sun,Susana M. Chuva de Sousa Lopes,Sarah K. Howlett,Amanda Clarkson,Lars Ährlund-Richter,Roger A. Pedersen,Ludovic Vallier +10 more
TL;DR: It is shown that pluripotent stem cells can be derived from the late epiblast layer of post-implantation mouse and rat embryos using chemically defined, activin-containing culture medium that is sufficient for long-term maintenance of human embryonic stem cells.
Journal ArticleDOI
Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells.
TL;DR: It is reported that Activin/Nodal signalling through Smad2/3 activation is necessary to maintain the pluripotent status of hESCs, and this findings suggest that the Activin / Nodal pathway maintains pluripotency through mechanism(s) in which FGF acts as a competence factor.
Journal ArticleDOI
Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells
Kosuke Yusa,S. Tamir Rashid,Helene Strick-Marchand,Helene Strick-Marchand,Ignacio Varela,Pei-Qi Liu,David Paschon,Elena Miranda,Elena Miranda,Adriana Ordóñez,Nicholas R.F. Hannan,Foad J. Rouhani,Foad J. Rouhani,Sylvie Darche,Sylvie Darche,Graeme J.M. Alexander,Stefan J. Marciniak,Noemi Fusaki,Mamoru Hasegawa,Michael C. Holmes,James P. Di Santo,James P. Di Santo,David A. Lomas,Allan Bradley,Ludovic Vallier +24 more
TL;DR: This work shows that a combination of zinc finger nucleases (ZFNs) and piggyBac technology in human iPSCs can achieve biallelic correction of a point mutation in the α1-antitrypsin (A1AT, also known as SERPINA1) gene that is responsible for α1
Journal ArticleDOI
Senescence impairs successful reprogramming to pluripotent stem cells
Ana Banito,Sheikh Tamir Rashid,Juan Carlos Acosta,Si De Li,Carlos Filipe Pereira,Imbisaat Geti,Sandra Pinho,José C. R. Silva,Véronique Azuara,Martin J. Walsh,Ludovic Vallier,Jesús Gil +11 more
TL;DR: Crucially, ablation of different senescence effectors improves the efficiency of reprogramming, suggesting novel strategies for maximizing the generation of iPS cells.
Journal ArticleDOI
Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells
S. Tamir Rashid,Sébastien Corbineau,Nicholas R.F. Hannan,Stefan J. Marciniak,Elena Miranda,Graeme J.M. Alexander,Isabel Huang-Doran,Julian L. Griffin,Lars Ährlund-Richter,Jeremy N. Skepper,Robert K. Semple,Anne Weber,David A. Lomas,Ludovic Vallier +13 more
TL;DR: These patient-derived hepatocytes demonstrate that it is possible to model diseases whose phenotypes are caused by pathological dysregulation of key processes within adult cells, and a simple and effective platform for hepatocyte generation from patient-specific human iPS cells.