L
Luis Barbeito
Researcher at Pasteur Institute
Publications - 42
Citations - 2306
Luis Barbeito is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Amyotrophic lateral sclerosis & Neuroinflammation. The author has an hindex of 19, co-authored 42 publications receiving 1383 citations. Previous affiliations of Luis Barbeito include University of the Republic.
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Journal ArticleDOI
Reactive astrocyte nomenclature, definitions, and future directions
Carole Escartin,Elena Galea,Andras Lakatos,James P. O'Callaghan,Gabor C. Petzold,Gabor C. Petzold,Alberto Serrano-Pozo,Christian Steinhäuser,Andrea Volterra,Giorgio Carmignoto,Giorgio Carmignoto,Amit Agarwal,Nicola J. Allen,Alfonso Araque,Luis Barbeito,Ari Barzilai,Dwight E. Bergles,Gilles Bonvento,Arthur M. Butt,Wei Ting Chen,Martine Cohen-Salmon,Colm Cunningham,Benjamin Deneen,Bart De Strooper,Bart De Strooper,Blanca Diaz-Castro,Cinthia Farina,Marc R. Freeman,Vittorio Gallo,James E. Goldman,Steven A. Goldman,Steven A. Goldman,Magdalena Götz,Antonia Gutierrez,Philip G. Haydon,Dieter Henrik Heiland,Elly M. Hol,Matthew Holt,Masamitsu Iino,Ksenia V. Kastanenka,Helmut Kettenmann,Baljit S. Khakh,Schuichi Koizumi,C. Justin Lee,Shane A. Liddelow,Brian A. MacVicar,Pierre J. Magistretti,Pierre J. Magistretti,Albee Messing,Anusha Mishra,Anna V. Molofsky,Keith K. Murai,Christopher M. Norris,Seiji Okada,Stéphane H. R. Oliet,João Filipe Oliveira,João Filipe Oliveira,Aude Panatier,Vladimir Parpura,Marcela Pekna,Milos Pekny,Luc Pellerin,Gertrudis Perea,Beatriz G. Pérez-Nievas,Frank W. Pfrieger,Kira E. Poskanzer,Francisco J. Quintana,Richard M. Ransohoff,Miriam Riquelme-Perez,Stefanie Robel,Christine R. Rose,Jeffrey D. Rothstein,Nathalie Rouach,David H. Rowitch,Alexey Semyanov,Alexey Semyanov,Swetlana Sirko,Harald Sontheimer,Raymond A. Swanson,Javier Vitorica,Ina B. Wanner,Levi B. Wood,Jia Qian Wu,Binhai Zheng,Eduardo R. Zimmer,Robert Zorec,Michael V. Sofroniew,Alexei Verkhratsky,Alexei Verkhratsky +88 more
TL;DR: In this article, the authors point out the shortcomings of binary divisions of reactive astrocytes into good-vs-bad, neurotoxic vs-neuroprotective or A1-vs.A2.
Journal ArticleDOI
Extracellular ATP and the P2X7 receptor in astrocyte-mediated motor neuron death: implications for amyotrophic lateral sclerosis
Mandi Gandelman,Mandi Gandelman,Hugo Peluffo,Hugo Peluffo,Joseph S. Beckman,Patricia Cassina,Luis Barbeito +6 more
TL;DR: The role of extracellular ATP acting through P2X7 receptors as an initiator of a neurotoxic phenotype that leads to astrocyte-mediated motor neuron death in non-transgenic and SOD1G93A astroCytes is studied.
Journal ArticleDOI
Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SODG93A mice co-expressing the Copper-Chaperone-for-SOD
Jared R. Williams,Emiliano Trias,Pamela R. Beilby,Nathan I. Lopez,Edwin M. Labut,C. Samuel Bradford,Blaine R. Roberts,Erin J. McAllum,Peter J. Crouch,Timothy W. Rhoads,Cliff Pereira,Marjatta Son,Jeffrey L. Elliott,Maria Clara Franco,Alvaro G. Estévez,Luis Barbeito,Joseph S. Beckman +16 more
TL;DR: Restoring CuATSM treatment could rescue these mice after they became symptomatic, providing a means to start and stop disease progression, and it is hoped that familial SOD ALS patients could respond to CuAT SM treatment similarly to the CCSxSOD mice.
Journal ArticleDOI
Neuroprotective effects of the mitochondria-targeted antioxidant MitoQ in a model of inherited amyotrophic lateral sclerosis.
Ernesto Miquel,Adriana Cassina,Laura Martínez-Palma,José M. Souza,Carmen Bolatto,Sebastián Rodríguez-Bottero,Angela Logan,Robin A.J. Smith,Michael P. Murphy,Luis Barbeito,Rafael Radi,Patricia Cassina +11 more
TL;DR: A role for mitochondrial nitroxidative damage and dysfunction in the pathogenesis of ALS is supported and it is suggested that mitochondria-targeted antioxidants may be of pharmacological use for ALS treatment.
Journal ArticleDOI
Post-paralysis tyrosine kinase inhibition with masitinib abrogates neuroinflammation and slows disease progression in inherited amyotrophic lateral sclerosis
Emiliano Trias,Sofía Ibarburu,Romina Barreto-Núñez,Joel Babdor,Thiago Trovati Maciel,Matthias Guillo,Laurent Gros,Patrice Dubreuil,Pablo Díaz-Amarilla,Patricia Cassina,Laura Martínez-Palma,Ivan C. Moura,Joseph S. Beckman,Olivier Hermine,Luis Barbeito +14 more
TL;DR: Data show that masitinib is capable of controlling microgliosis and the emergence/expansion of aberrant glial cells, thus providing a strong biological rationale for its use to control neuroinflammation in ALS.