Mark M. Davis

TL;DR: The data suggest that γδ IELs may respond efficiently to a broad range of pathological situations irrespective of their diverse T cell antigen receptor repertoire, and may modulate local immune responses and participate in intestinal lipid metabolism, cholesterol homeostasis, and physiology.

TL;DR: A method using combinations of fluorescent pMHC tetramers to simultaneously detect and enrich for many T-cell specificities in a single human blood sample is described and validated.

TL;DR: A murine class II major histocompatibility complex (MHC) heterodimer expressed as a glycan-phosphatidyl inositol-anchored chimera on Chinese Hamster Ovary cells, can present peptides, but not processed antigen to T cells, suggests that class II MHC molecules undergo distinct conformational changes in endosomal compartments that render them more capable of forming functional complexes with peptide antigens, irrespective of other cell components.

TL;DR: Current knowledge of the biology of SARS-CoV-2 and the potential mechanisms of myocardial injury due to viral toxicities and host immune responses are reviewed.

TL;DR: A key role is identified in age-related chronic inflammation of CXCL9 in cardiac aging, adverse cardiac remodeling and poor vascular function and a metric for multimorbidity is derived that can be utilized for the early detection of age- related clinical phenotypes.