Mark M. Davis

TL;DR: It is demonstrated that the cell surface protein CD38 is a key human NK cell functional receptor through a role in immune synapse formation and opens new avenues in immunotherapeutic development for cancer and infection by revealing a critical role for CD38 in NK cell function.

TL;DR: A comprehensive immune response map spanning 454 proteins and 847 metabolites in plasma integrated with single-cell multi-omic assays of PBMCs is presented in which whole transcriptome, 192 surface proteins, and T and B cell receptor sequence were co-analyzed within the context of clinical measures from 50 COVID19 patient samples.

TL;DR: The tools and techniques of data warehousing, including open-source business intelligence software, are used to support investigator-driven data integration and mining of diverse immunological data and can be used to find gender-specific differences in serum cytokine levels.

TL;DR: In this article, a cell surface protein which contains certain classical cadherin characteristics, but exhibits an apical distribution pattern on the surface of lymphocytes, is described and the membrane location correlates with the contact interface between T and B cells, and antibodies against an extracellular domain of this protein disrupt T cell/B cell interactions.

TL;DR: In this paper , the authors used single-cell technology and in vitro assays to interrogate the immune microenvironment of human coronary atherosclerotic plaque at different stages of maturity.