M
Mark M. Davis
Researcher at Stanford University
Publications - 623
Citations - 84251
Mark M. Davis is an academic researcher from Stanford University. The author has contributed to research in topics: T cell & T-cell receptor. The author has an hindex of 144, co-authored 581 publications receiving 74358 citations. Previous affiliations of Mark M. Davis include Washington University in St. Louis & University of Chicago.
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Journal ArticleDOI
T cells use two directionally distinct pathways for cytokine secretion.
Morgan Huse,Björn F. Lillemeier,Michael S. Kuhns,Daniel S. Chen,Daniel S. Chen,Mark M. Davis,Mark M. Davis +6 more
TL;DR: The data suggest that T helper cells release some cytokines into the immunological synapse to impart specific communication and others multidirectionally to promote inflammation and to establish chemokine gradients.
Journal ArticleDOI
The nature of major histocompatibility complex recognition by γδ T cells
Hansjörg Schild,Nasim Mavaddat,Nasim Mavaddat,Christa Litzenberger,Elliot W. Ehrich,Mark M. Davis,Mark M. Davis,Jeffrey A. Bluestone,Louis Matis,Rockford K. Draper,Yueh-hsiu Chien +10 more
TL;DR: It is found that the activation of these clones requires neither class I nor class II antigen-processing and that peptides do not confer specificity, suggesting the molecular nature of γδ T cell recognition is fundamentally different than that of αβ T cells.
Journal ArticleDOI
Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19.
Yapeng Su,Daniel Chen,Dan Yuan,Christopher Lausted,Jongchan Choi,Chengzhen L. Dai,Valentin Voillet,Venkata R Duvvuri,Kelsey Scherler,Pamela Troisch,Priyanka Baloni,Guangrong Qin,Brett Smith,Sergey A. Kornilov,Clifford Rostomily,Alexander M. Xu,Jing Li,Shen Dong,Alissa C. Rothchild,Jing Zhou,Kim Murray,Rick Edmark,Sunga Hong,John E. Heath,John C. Earls,Rongyu Zhang,Jingyi Xie,Sarah Li,Ryan Roper,Lesley Jones,Yong Zhou,Lee Rowen,Rachel Liu,Sean Mackay,D. Shane O’Mahony,Christopher R. Dale,Julie A. Wallick,Heather A. Algren,Michael Zager,Wei Wei,Nathan D. Price,Sui Huang,Naeha Subramanian,Kai Wang,Andrew T. Magis,Jenn J. Hadlock,Leroy Hood,Alan Aderem,Jeffrey A. Bluestone,Lewis L. Lanier,Philip D. Greenberg,Raphael Gottardo,Mark M. Davis,Jason D Goldman,James R. Heath +54 more
TL;DR: It is suggested that moderate disease may provide the most effective setting for therapeutic intervention, at which point elevated inflammatory signaling is accompanied by the loss of specific classes of metabolites and metabolic processes at moderate disease.
Journal ArticleDOI
Virus-Specific CD4+ Memory-Phenotype T Cells Are Abundant in Unexposed Adults
TL;DR: The presence of memory-phenotype T cells in adults who had never been infected with HIV or influenza has significant implications for immunity to novel pathogens, child and adult health, and the influence of pathogen-rich versus hygienic environments.
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Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients
Tobias Deuse,X. Hu,Alessia Gravina,Dong Wang,Grigol Tediashvili,Chandrav De,William O. Thayer,Angela Wahl,J. Victor Garcia,Hermann Reichenspurner,Mark M. Davis,Lewis L. Lanier,Sonja Schrepfer +12 more
TL;DR: It is shown that both mouse and human iPSCs lose their immunogenicity when major histocompatibility complex (MHC) class I and II genes are inactivated and CD47 is over-expressed, which suggests that hypoimmunogenic cell grafts can be engineered for universal transplantation.