M
Mark M. Davis
Researcher at Stanford University
Publications - 623
Citations - 84251
Mark M. Davis is an academic researcher from Stanford University. The author has contributed to research in topics: T cell & T-cell receptor. The author has an hindex of 144, co-authored 581 publications receiving 74358 citations. Previous affiliations of Mark M. Davis include Washington University in St. Louis & University of Chicago.
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Posted ContentDOI
CD38 is a key regulator of enhanced NK cell immune responses during pregnancy through its role in immune synapse formation
Mathieu Le Gars,Christof Seiler,Alexander W. Kay,Nicholas L. Bayless,Elina Starosvetsky,Lindsay Moore,Shai S. Shen-Orr,Natali Aziz,Cornelia L. Dekker,Purvesh Khatri,Gary E. Swan,Mark M. Davis,Susan Holmes,Catherine A. Blish +13 more
TL;DR: Increased CD38 expression directly promotes enhanced NK cell responses during pregnancy through its role in immune synapse formation, which opens new avenues in immunotherapeutic development for cancer and viruses.
Journal ArticleDOI
Integrated single-cell transcriptomics and epigenomics reveals strong germinal center-associated etiology of autoimmune risk loci.
Hamish W King,Kristen L. Wells,Kristen L. Wells,Zohar Shipony,Arwa Kathiria,Lisa E. Wagar,Lisa E. Wagar,Caleb A. Lareau,Caleb A. Lareau,Nara Orban,Robson Capasso,Mark M. Davis,Mark M. Davis,Lars M. Steinmetz,Louisa K. James,William J. Greenleaf +15 more
TL;DR: The germinal center (GC) response is critical for both effective adaptive immunity and establishing peripheral tolerance by limiting autoreactive B cells as discussed by the authors, and dysfunction in these processes can lead to...
Journal ArticleDOI
Distinct immune characteristics distinguish hereditary and idiopathic chronic pancreatitis.
Bomi Lee,Julia Z. Adamska,Hong Namkoong,Melena D. Bellin,Joshua J. Wilhelm,Gregory L. Szot,David M. Louis,Mark M. Davis,Stephen J. Pandol,Aida Habtezion +9 more
TL;DR: Immunophenotyping analyses in hereditary and idiopathic CP pancreata indicate differences in innate and adaptive immune responses, which highlights differences in immunopathogenic mechanism of disease among subtypes of CP.
Journal ArticleDOI
Allergen-specific CD8+ T cells in peanut-allergic individuals
Wong Yu,Xiaoying Zhou,Diane M. Dunham,Shu Chen Lyu,Monali Manohar,Wenming Zhang,Fan Zhao,Mark M. Davis,Kari C. Nadeau +8 more
TL;DR: It is shown that peanut specific CD8+ T cells are increased in peanut allergic human subjects, and IgE mediated food allergy is linked to increased T cells in these subjects.
Book ChapterDOI
Functional development of the T cell receptor for antigen.
TL;DR: Recent findings relating to T cell antigen recognition are discussed and how this leads to the thymic development of foreign-antigen-responsive alphabetaT cells are discussed.